3DQV
Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | NEDD8 | polymer | 81 | 9078.0 | 2 | UniProt (Q15843) Pfam (PF00240) In PDB | Homo sapiens (human) | Ubiquitin-like protein Nedd8, Neddylin |
2 | C, D | Cullin-5 | polymer | 382 | 45601.8 | 2 | UniProt (Q93034) Pfam (PF00888) Pfam (PF10557) In PDB | Homo sapiens (human) | CUL-5, Vasopressin-activated calcium-mobilizing receptor, VACM-1 |
3 | R, Y | Rbx1 | polymer | 106 | 12183.5 | 2 | UniProt (P62877) Pfam (PF12678) In PDB | Homo sapiens (human) | Rbx1, Regulator of cullins 1, RING finger protein 75, Protein ZYP |
4 | R, Y | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) |
Sequence modifications
A, B: 101 - 176 (UniProt: Q15843)
C, D: 1401 - 1780 (UniProt: Q93034)
R, Y: 5 - 108 (UniProt: P62877)
PDB | External Database | Details |
---|---|---|
Gly 96 | - | INSERTION |
Ser 97 | - | INSERTION |
Gly 98 | - | INSERTION |
Gly 99 | - | INSERTION |
Ser 100 | - | INSERTION |
Mse 162 | Leu 62 | CONFLICT |
PDB | External Database | Details |
---|---|---|
Gly 1399 | - | INSERTION |
Ser 1400 | - | INSERTION |
Glu 1407 | Leu 407 | CONFLICT |
Lys 1439 | Leu 439 | CONFLICT |
Lys 1440 | Val 440 | CONFLICT |
PDB | External Database | Details |
---|---|---|
Gly 3 | - | INSERTION |
Ser 4 | - | INSERTION |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 133726.6 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 392.5 | |
All* | Total formula weight | 134119.1 |