4WUR

The crystal structure of the MERS-CoV papain-like protease (C111S) with human ubiquitin

Summary for 4WUR

Related4P16
DescriptorPapain-like protease, Polyubiquitin-B, ISOPROPYL ALCOHOL, ... (4 entities in total)
Functional Keywordsmers-cov, papain-like protease, ubiquitin, complex, hydrolase
Biological sourceBetacoronavirus England 1 (HCoV-EMC)
More
Cellular locationPapain-like proteinase: Host membrane; Multi-pass membrane protein. Non-structural protein 4: Host membrane; Multi-pass membrane protein. Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region . Helicase: Host endoplasmic reticulum-Golgi intermediate compartment . Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region  K9N7C7
Ubiquitin: Cytoplasm  P0CG47
Total number of polymer chains2
Total molecular weight44917.97
Authors
Lei, J.,Hilgenfeld, R. (deposition date: 2014-11-03, release date: 2014-11-26)
Primary citation
Lei, J.,Hilgenfeld, R.
Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin.
Virol Sin, 31:288-299, 2016
PubMed: 27245450 (PDB entries with the same primary citation)
DOI: 10.1007/s12250-016-3742-4
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.16 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2471704.6%7.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report