4WUR

The crystal structure of the MERS-CoV papain-like protease (C111S) with human ubiquitin

Summary for 4WUR

• Entry DOI: 10.2210/pdb4wur/pdb
• Related: 4P16
• Descriptor: Papain-like protease, Polyubiquitin-B, ISOPROPYL ALCOHOL, ... (4 entities in total)
• Functional Keywords: mers-cov, papain-like protease, ubiquitin, complex, hydrolase
• Biological source: Human coronavirus EMC (HCoV-EMC); More
• Cellular location: Papain-like proteinase: Host membrane; Multi-pass membrane protein. Non-structural protein 4: Host membrane; Multi-pass membrane protein. Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region . Helicase: Host endoplasmic reticulum-Golgi intermediate compartment . Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region : K9N7C7; Ubiquitin: Cytoplasm : P0CG47
• Total number of polymer chains: 2
• Total formula weight: 44917.97

Authors

Lei, J.,Hilgenfeld, R. (deposition date: 2014-11-03, release date: 2014-11-26, Last modification date: 2024-01-10)

• Primary citation: Lei, J.,Hilgenfeld, R.; Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin.; Virol Sin, 31:288-299, 2016; PubMed: 27245450; DOI: 10.1007/s12250-016-3742-4

Experimental method

X-RAY DIFFRACTION (3.16 Å)