3GZN
Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924
Summary for 3GZN
Entry DOI | 10.2210/pdb3gzn/pdb |
Descriptor | NEDD8-activating enzyme E1 regulatory subunit, NEDD8-activating enzyme E1 catalytic subunit, NEDD8, ... (5 entities in total) |
Functional Keywords | nedd8, e1-activating enzyme, mln4924, protein binding-ligase complex, protein binding/ligase |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane: Q13564 Nucleus: Q15843 |
Total number of polymer chains | 6 |
Total formula weight | 244266.13 |
Authors | Sintchak, M.D. (deposition date: 2009-04-07, release date: 2010-02-02, Last modification date: 2023-09-06) |
Primary citation | Brownell, J.E.,Sintchak, M.D.,Gavin, J.M.,Liao, H.,Bruzzese, F.J.,Bump, N.J.,Soucy, T.A.,Milhollen, M.A.,Yang, X.,Burkhardt, A.L.,Ma, J.,Loke, H.K.,Lingaraj, T.,Wu, D.,Hamman, K.B.,Spelman, J.J.,Cullis, C.A.,Langston, S.P.,Vyskocil, S.,Sells, T.B.,Mallender, W.D.,Visiers, I.,Li, P.,Claiborne, C.F.,Rolfe, M.,Bolen, J.B.,Dick, L.R. Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ. Mol.Cell, 37:102-111, 2010 Cited by PubMed: 20129059DOI: 10.1016/j.molcel.2009.12.024 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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