3GZN
Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | NEDD8-activating enzyme E1 regulatory subunit | polymer | 534 | 60315.1 | 2 | UniProt (Q13564) Pfam (PF00899) In PDB | Homo sapiens (human) | Amyloid protein-binding protein 1, Amyloid beta precursor protein-binding protein 1, 59 kDa, APP-BP1, Proto-oncogene protein 1 |
2 | B, D | NEDD8-activating enzyme E1 catalytic subunit | polymer | 463 | 51906.2 | 2 | UniProt (Q8TBC4) Pfam (PF00899) Pfam (PF08825) In PDB | Homo sapiens (human) | Ubiquitin-like modifier-activating enzyme 3, Ubiquitin-activating enzyme 3, NEDD8-activating enzyme E1C, Ubiquitin-activating enzyme E1C |
3 | I, J | NEDD8 | polymer | 82 | 9402.9 | 2 | UniProt (Q15843) Pfam (PF00240) In PDB | Homo sapiens (human) | Ubiquitin-like protein Nedd8, Neddylin, Neural precursor cell expressed developmentally down-regulated protein 8, NEDD-8 |
4 | B, D | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
5 | I, J | [(1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate | non-polymer | 443.5 | 2 | Chemie (B39) |
Sequence modifications
I, J: 1 - 76 (UniProt: Q15843)
PDB | External Database | Details |
---|---|---|
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 243248.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1017.9 | |
All* | Total formula weight | 244266.1 |