3GZN
Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | NEDD8-activating enzyme E1 regulatory subunit | polymer | 534 | 60315.1 | 2 | UniProt (Q13564) Pfam (PF00899) | Homo sapiens (human) | Amyloid protein-binding protein 1, Amyloid beta precursor protein-binding protein 1, 59 kDa, APP-BP1, Proto-oncogene protein 1 |
| 2 | B, D (B, D) | NEDD8-activating enzyme E1 catalytic subunit | polymer | 463 | 51906.2 | 2 | UniProt (Q8TBC4) Pfam (PF00899) Pfam (PF08825) | Homo sapiens (human) | Ubiquitin-like modifier-activating enzyme 3, Ubiquitin-activating enzyme 3, NEDD8-activating enzyme E1C, Ubiquitin-activating enzyme E1C |
| 3 | E, F (I, J) | NEDD8 | polymer | 82 | 9402.9 | 2 | UniProt (Q15843) Pfam (PF00240) | Homo sapiens (human) | Ubiquitin-like protein Nedd8, Neddylin, Neural precursor cell expressed developmentally down-regulated protein 8, NEDD-8 |
| 4 | G, H (B, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | I, J (I, J) | [(1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate | non-polymer | 443.5 | 2 | Chemie (B39) PubChem (16720766) PubChem (24966999) PubChem (24968962) PubChem (49831043) PubChem (56603703) PubChem (60167557) PubChem (71729979) PubChem (73014187) PubChem (88557248) PubChem (90131721) PubChem (91885500) PubChem (124930201) PubChem (122172972) PubChem (124604730) PubChem (124628807) PubChem (11996605) PubChem (166748427) PubChem (130348291) PubChem (137374920) PubChem (162470842) PubChem (163782558) PubChem (169436174) PubChem (171395883) PubChem (173888202) |
Sequence modifications
I, J: 1 - 76 (UniProt: Q15843)
| PDB | External Database | Details |
|---|---|---|
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 243248.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1017.9 | |
| All* | Total formula weight | 244266.1 |
