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3GZN

Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924

Functional Information from GO Data
ChainGOidnamespacecontents
A0004839molecular_functionubiquitin activating enzyme activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006511biological_processubiquitin-dependent protein catabolic process
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007165biological_processsignal transduction
A0008641molecular_functionubiquitin-like modifier activating enzyme activity
A0016567biological_processprotein ubiquitination
A0019781molecular_functionNEDD8 activating enzyme activity
A0031625molecular_functionubiquitin protein ligase binding
A0032991cellular_componentprotein-containing complex
A0033314biological_processmitotic DNA replication checkpoint signaling
A0042981biological_processregulation of apoptotic process
A0043523biological_processregulation of neuron apoptotic process
A0045116biological_processprotein neddylation
A0046982molecular_functionprotein heterodimerization activity
A0051402biological_processneuron apoptotic process
B0000278biological_processmitotic cell cycle
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006508biological_processproteolysis
B0007113biological_processendomitotic cell cycle
B0008641molecular_functionubiquitin-like modifier activating enzyme activity
B0016874molecular_functionligase activity
B0019781molecular_functionNEDD8 activating enzyme activity
B0019788molecular_functionNEDD8 transferase activity
B0032991cellular_componentprotein-containing complex
B0036211biological_processprotein modification process
B0042802molecular_functionidentical protein binding
B0043687biological_processpost-translational protein modification
B0045116biological_processprotein neddylation
B0046982molecular_functionprotein heterodimerization activity
B0051726biological_processregulation of cell cycle
C0004839molecular_functionubiquitin activating enzyme activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006511biological_processubiquitin-dependent protein catabolic process
C0006915biological_processapoptotic process
C0006974biological_processDNA damage response
C0007165biological_processsignal transduction
C0008641molecular_functionubiquitin-like modifier activating enzyme activity
C0016567biological_processprotein ubiquitination
C0019781molecular_functionNEDD8 activating enzyme activity
C0031625molecular_functionubiquitin protein ligase binding
C0032991cellular_componentprotein-containing complex
C0033314biological_processmitotic DNA replication checkpoint signaling
C0042981biological_processregulation of apoptotic process
C0043523biological_processregulation of neuron apoptotic process
C0045116biological_processprotein neddylation
C0046982molecular_functionprotein heterodimerization activity
C0051402biological_processneuron apoptotic process
D0000278biological_processmitotic cell cycle
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006508biological_processproteolysis
D0007113biological_processendomitotic cell cycle
D0008641molecular_functionubiquitin-like modifier activating enzyme activity
D0016874molecular_functionligase activity
D0019781molecular_functionNEDD8 activating enzyme activity
D0019788molecular_functionNEDD8 transferase activity
D0032991cellular_componentprotein-containing complex
D0036211biological_processprotein modification process
D0042802molecular_functionidentical protein binding
D0043687biological_processpost-translational protein modification
D0045116biological_processprotein neddylation
D0046982molecular_functionprotein heterodimerization activity
D0051726biological_processregulation of cell cycle
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005829cellular_componentcytosol
I0006357biological_processregulation of transcription by RNA polymerase II
I0006508biological_processproteolysis
I0006511biological_processubiquitin-dependent protein catabolic process
I0008104biological_processprotein localization
I0009653biological_processanatomical structure morphogenesis
I0016567biological_processprotein ubiquitination
I0019941biological_processmodification-dependent protein catabolic process
I0030162biological_processregulation of proteolysis
I0031386molecular_functionprotein tag activity
I0031625molecular_functionubiquitin protein ligase binding
I0036211biological_processprotein modification process
I0045116biological_processprotein neddylation
I0070062cellular_componentextracellular exosome
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005829cellular_componentcytosol
J0006357biological_processregulation of transcription by RNA polymerase II
J0006508biological_processproteolysis
J0006511biological_processubiquitin-dependent protein catabolic process
J0008104biological_processprotein localization
J0009653biological_processanatomical structure morphogenesis
J0016567biological_processprotein ubiquitination
J0019941biological_processmodification-dependent protein catabolic process
J0030162biological_processregulation of proteolysis
J0031386molecular_functionprotein tag activity
J0031625molecular_functionubiquitin protein ligase binding
J0036211biological_processprotein modification process
J0045116biological_processprotein neddylation
J0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE B39 J 464
ChainResidue
DGLY78
DILE148
DGLN149
DGLY165
DASP167
DALA171
DTRP174
JGLY76
DGLY79
DASP100
DMET101
DARG111
DGLN112
DLYS124
DASN146
DLYS147

site_idAC2
Number of Residues16
DetailsBINDING SITE FOR RESIDUE B39 I 464
ChainResidue
BGLY78
BGLY79
BASP100
BMET101
BASP102
BARG111
BGLN112
BLYS124
BASN146
BLYS147
BILE148
BGLN149
BASP167
BALA171
BTRP174
IGLY76

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 465
ChainResidue
BCYS220
BCYS223
BCYS364
BCYS367

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 465
ChainResidue
DCYS220
DCYS223
DCYS364
DCYS367

Functional Information from PROSITE/UniProt
site_idPS00299
Number of Residues26
DetailsUBIQUITIN_1 Ubiquitin domain signature. KerVeEkegIPpqqQrLIYsGkqmnD
ChainResidueDetails
ILYS27-ASP52

site_idPS00865
Number of Residues9
DetailsUBIQUITIN_ACTIVAT_2 Ubiquitin-activating enzyme active site. PMCTIAsMP
ChainResidueDetails
BPRO235-PRO243

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsSITE: Interaction with UBE1C => ECO:0000269|PubMed:14690597
ChainResidueDetails
ILEU8
IILE44
JLEU8
JILE44

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: (Microbial infection) Deamidated glutamine => ECO:0000269|PubMed:20688984, ECO:0000269|PubMed:21903097, ECO:0000269|PubMed:23175788, ECO:0000269|PubMed:23589306, ECO:0000269|PubMed:26632597
ChainResidueDetails
IGLN40
JGLN40
DASP100
DILE148

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P29595
ChainResidueDetails
ILYS48
JLYS48

site_idSWS_FT_FI4
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
ChainResidueDetails
IGLY76
DALA2
JGLY76

222415

PDB entries from 2024-07-10

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