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6ZPN
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BU of 6zpn by Molmil
Crystal structure of Chaetomium thermophilum Raptor
Descriptor: WD_REPEATS_REGION domain-containing protein
Authors:Imseng, S, Boehm, R, Jakob, R.P, Hall, M.N, Hiller, S, Maier, T.
Deposit date:2020-07-08
Release date:2021-05-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1.
Mol.Cell, 81, 2021
3LQ9
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BU of 3lq9 by Molmil
Crystal structure of human REDD1, a hypoxia-induced regulator of mTOR
Descriptor: DNA-damage-inducible transcript 4 protein
Authors:Vega-Rubin-de-Celis, S, Abdallah, Z, Brugarolas, J, Zhang, X.
Deposit date:2010-02-08
Release date:2010-03-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis and functional implications of the negative mTORC1 regulator REDD1.
Biochemistry, 49, 2010
7N93
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BU of 7n93 by Molmil
P70 S6K1 IN COMPLEX WITH MSC2363318A-1
Descriptor: 4-({(1S)-2-(azetidin-1-yl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl}amino)quinazoline-8-carboxamide, Ribosomal protein S6 kinase beta-1
Authors:Mochalkin, I.
Deposit date:2021-06-16
Release date:2022-07-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.
J.Med.Chem., 64, 2021
7N91
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BU of 7n91 by Molmil
P70 S6K1 IN COMPLEX WITH MSC2317067A-1
Descriptor: 4-{[(1S)-1-(3-fluorophenyl)-2-(methylamino)ethyl]amino}quinazoline-8-carboxamide, Ribosomal protein S6 kinase beta-1
Authors:Mochalkin, I.
Deposit date:2021-06-16
Release date:2022-07-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.
J.Med.Chem., 64, 2021
5GT8
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BU of 5gt8 by Molmil
Crystal Structure of apo-CASTOR1
Descriptor: GATS-like protein 3
Authors:Guo, L, Deng, D.
Deposit date:2016-08-18
Release date:2017-08-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states
Biochem. Biophys. Res. Commun., 508, 2019
5GT7
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BU of 5gt7 by Molmil
Crystal Structure of Arg-bound CASTOR1
Descriptor: ARGININE, GATS-like protein 3, MALONATE ION
Authors:Guo, L, Deng, D.
Deposit date:2016-08-18
Release date:2017-08-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.048 Å)
Cite:Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states
Biochem. Biophys. Res. Commun., 508, 2019
7UNF
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BU of 7unf by Molmil
CryoEM structure of a mEAK7 bound human V-ATPase complex
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Wang, R, Li, X.
Deposit date:2022-04-10
Release date:2022-06-15
Last modified:2022-06-29
Method:ELECTRON MICROSCOPY (4.08 Å)
Cite:Molecular basis of mEAK7-mediated human V-ATPase regulation.
Nat Commun, 13, 2022
7UNE
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BU of 7une by Molmil
The V1 region of bovine V-ATPase in complex with human mEAK7 (focused refinement)
Descriptor: KIAA1609 protein, isoform CRA_a, V-type proton ATPase catalytic subunit A, ...
Authors:Wang, R, Li, X.
Deposit date:2022-04-10
Release date:2022-06-15
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.73 Å)
Cite:Molecular basis of mEAK7-mediated human V-ATPase regulation.
Nat Commun, 13, 2022
6ULG
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BU of 6ulg by Molmil
Cryo-EM structure of the FLCN-FNIP2-Rag-Ragulator complex
Descriptor: Folliculin, Folliculin-interacting protein 2, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Shen, K, Rogala, K.B, Yu, Z.H, Sabatini, D.M.
Deposit date:2019-10-08
Release date:2019-11-20
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.
Cell, 179, 2019
5X6U
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BU of 5x6u by Molmil
Crystal structure of human heteropentameric complex
Descriptor: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ...
Authors:Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M.
Deposit date:2017-02-23
Release date:2017-12-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Nat Commun, 8, 2017
5X6V
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BU of 5x6v by Molmil
Crystal structure of human heteroheptameric complex
Descriptor: ACETATE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ...
Authors:Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M.
Deposit date:2017-02-23
Release date:2017-12-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Nat Commun, 8, 2017
3IBE
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BU of 3ibe by Molmil
Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to PI3 Kinase Gamma
Descriptor: 1-(4-{4-morpholin-4-yl-1-[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenyl)-3-pyridin-4-ylurea, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
Authors:Bard, J, Svenson, K.
Deposit date:2009-07-15
Release date:2009-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.798 Å)
Cite:ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines.
J.Med.Chem., 52, 2009
6NZD
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BU of 6nzd by Molmil
Cryo-EM Structure of the Lysosomal Folliculin Complex (FLCN-FNIP2-RagA-RagC-Ragulator)
Descriptor: 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione, Folliculin, Folliculin-interacting protein 2, ...
Authors:Fromm, S.A, Young, L.N, Hurley, J.H.
Deposit date:2019-02-13
Release date:2019-11-06
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
Science, 366, 2019
6WJ3
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BU of 6wj3 by Molmil
CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the post-GAP state
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ...
Authors:Fromm, S.A, Hurley, J.H.
Deposit date:2020-04-11
Release date:2020-09-02
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.
Nat.Struct.Mol.Biol., 27, 2020
6WJ2
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BU of 6wj2 by Molmil
CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the pre-GAP state
Descriptor: 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Fromm, S.A, Hurley, J.H.
Deposit date:2020-04-11
Release date:2020-09-02
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.
Nat.Struct.Mol.Biol., 27, 2020
5Y39
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BU of 5y39 by Molmil
Crystal structure of Ragulator complex (p18 76-145)
Descriptor: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ...
Authors:Zhang, T, Ding, J.
Deposit date:2017-07-28
Release date:2017-12-06
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
Nat Commun, 8, 2017
5Y3A
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BU of 5y3a by Molmil
Crystal structure of Ragulator complex (p18 49-161)
Descriptor: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ...
Authors:Zhang, T, Ding, J.
Deposit date:2017-07-28
Release date:2017-12-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.
Nat Commun, 8, 2017
2L0X
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BU of 2l0x by Molmil
Solution structure of the 21 kDa GTPase RHEB bound to GDP
Descriptor: GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Stoll, R, Heumann, R, Berghaus, C, Kock, G.
Deposit date:2010-07-19
Release date:2010-08-04
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Ras homolog enriched in brain (Rheb) enhances apoptotic signaling.
J.Biol.Chem., 285, 2010
6B9X
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BU of 6b9x by Molmil
Crystal structure of Ragulator
Descriptor: Hepatitis B virus x interacting protein, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ...
Authors:SU, M.-Y, Hurley, J.H.
Deposit date:2017-10-11
Release date:2017-11-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.
Mol. Cell, 68, 2017
3L08
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BU of 3l08 by Molmil
Structure of Pi3K gamma with a potent inhibitor: GSK2126458
Descriptor: 2,4-difluoro-N-[2-methoxy-5-(4-pyridazin-4-ylquinolin-6-yl)pyridin-3-yl]benzenesulfonamide, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
Authors:Elkins, P.A, Marrero, E.M.
Deposit date:2009-12-09
Release date:2010-06-23
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.
ACS Med Chem Lett, 1, 2010
7T3B
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BU of 7t3b by Molmil
GATOR1-RAG-RAGULATOR - GAP Complex
Descriptor: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ...
Authors:Egri, S.B, Shen, K.
Deposit date:2021-12-07
Release date:2022-04-06
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
7T3A
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BU of 7t3a by Molmil
GATOR1-RAG-RAGULATOR - Inhibitory Complex
Descriptor: GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ...
Authors:Egri, S.B, Shen, K.
Deposit date:2021-12-07
Release date:2022-04-06
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
7T3C
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BU of 7t3c by Molmil
GATOR1-RAG-RAGULATOR - Dual Complex
Descriptor: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ...
Authors:Egri, S.B, Shen, K.
Deposit date:2021-12-07
Release date:2022-04-06
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
8DHB
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BU of 8dhb by Molmil
Active FLCN GAP complex
Descriptor: BERYLLIUM TRIFLUORIDE ION, Folliculin, Folliculin-interacting protein 2, ...
Authors:Jansen, R.M, Hurley, J.H.
Deposit date:2022-06-25
Release date:2022-09-28
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.
Sci Adv, 8, 2022
5WBL
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BU of 5wbl by Molmil
Crystal structure of the Arabidopsis thaliana Raptor in complex with the TOS peptide of human PRAS40
Descriptor: Proline-rich AKT1 substrate 1, Regulatory-associated protein of TOR 1
Authors:Pavletich, N.P, Jiang, X.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017

221051

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