4NRW
| MvNei1-G86D | Descriptor: | 5'-D(*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*C)-3', 5'-D(*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3', formamidopyrimidine-DNA glycosylase | Authors: | Prakash, A, Doublie, S. | Deposit date: | 2013-11-27 | Release date: | 2014-01-01 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.845 Å) | Cite: | Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: Activity, structure, and the effect of editing. Dna Repair, 14, 2014
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4MXW
| Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab | Descriptor: | Lymphotoxin-alpha, Lymphotoxin-beta, Tumor necrosis factor receptor superfamily member 3, ... | Authors: | Sudhamsu, J, Yin, J.P, Hymowitz, S.G. | Deposit date: | 2013-09-26 | Release date: | 2013-11-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Dimerization of LT beta R by LT alpha 1 beta 2 is necessary and sufficient for signal transduction. Proc.Natl.Acad.Sci.USA, 110, 2013
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4L95
| Crystal structure of gamma glutamyl hydrolase (H218N) from zebrafish | Descriptor: | GLYCEROL, Gamma-glutamyl hydrolase | Authors: | Chuankhayan, P, Kao, T.-T, Chen, C.-J, Fu, T.-F. | Deposit date: | 2013-06-18 | Release date: | 2014-05-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase J.Med.Chem., 56, 2013
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4MXV
| Structure of Lymphotoxin alpha bound to anti-LTa Fab | Descriptor: | Lymphotoxin-alpha, anti-Lymphotoxin alpha antibody heavy chain, anti-Lymphotoxin alpha antibody light chain | Authors: | Yin, J.P, Hymowitz, S.G. | Deposit date: | 2013-09-26 | Release date: | 2013-11-13 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Dimerization of LT beta R by LT alpha 1 beta 2 is necessary and sufficient for signal transduction. Proc.Natl.Acad.Sci.USA, 110, 2013
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4NRV
| Crystal Structure of non-edited human NEIL1 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Endonuclease 8-like 1 | Authors: | Prakash, A, Doublie, S. | Deposit date: | 2013-11-27 | Release date: | 2014-01-01 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.601 Å) | Cite: | Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: Activity, structure, and the effect of editing. Dna Repair, 14, 2014
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1R67
| Y104A MUTANT OF E.COLI IPP ISOMERASE | Descriptor: | Isopentenyl-diphosphate delta-isomerase, MAGNESIUM ION | Authors: | Wouters, J. | Deposit date: | 2003-10-15 | Release date: | 2003-10-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Structural role for Tyr-104 in Escherichia coli isopentenyl-diphosphate isomerase: site-directed mutagenesis, enzymology, and protein crystallography. J.Biol.Chem., 281, 2006
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2BI6
| NMR STUDY OF BROMELAIN INHIBITOR VI FROM PINEAPPLE STEM | Descriptor: | BROMELAIN INHIBITOR VI | Authors: | Hatano, K.-I. | Deposit date: | 1995-12-07 | Release date: | 1996-04-03 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | Solution structure of bromelain inhibitor IV from pineapple stem: structural similarity with Bowman-Birk trypsin/chymotrypsin inhibitor from soybean. Biochemistry, 35, 1996
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8OXK
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8OXJ
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8PHY
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3SQE
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3T6P
| IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization | Descriptor: | Baculoviral IAP repeat-containing protein 2, ZINC ION | Authors: | Dueber, E.C, Schoeffler, A.J, Lingel, A, Elliott, M, Fedorova, A.V, Giannetti, A.M, Zobel, K, Maurer, B, Varfolomeev, E, Wu, P, Wallweber, H, Hymowitz, S, Deshayes, K, Vucic, D, Fairbrother, W.J. | Deposit date: | 2011-07-28 | Release date: | 2011-11-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.897 Å) | Cite: | Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination. Science, 334, 2011
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8QXB
| TDP-43 amyloid fibrils: Morphology-2 | Descriptor: | TAR DNA-binding protein 43 | Authors: | Sharma, K, Shenoy, J, Loquet, A, Schmidt, M, Faendrich, M. | Deposit date: | 2023-10-24 | Release date: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | Cryo-EM observation of the amyloid key structure of polymorphic TDP-43 amyloid fibrils. Nat Commun, 15, 2024
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8QXA
| TDP-43 amyloid fibrils: Morphology-1b | Descriptor: | TAR DNA-binding protein 43 | Authors: | Sharma, K, Shenoy, J, Loquet, A, Schmidt, M, Faendrich, M. | Deposit date: | 2023-10-24 | Release date: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (4.05 Å) | Cite: | Cryo-EM observation of the amyloid key structure of polymorphic TDP-43 amyloid fibrils. Nat Commun, 15, 2024
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8QX9
| TDP-43 amyloid fibrils: Morphology-1a | Descriptor: | TAR DNA-binding protein 43 | Authors: | Sharma, K, Shenoy, J, Loquet, A, Schmidt, M, Faendrich, M. | Deposit date: | 2023-10-24 | Release date: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.76 Å) | Cite: | Cryo-EM observation of the amyloid key structure of polymorphic TDP-43 amyloid fibrils. Nat Commun, 15, 2024
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2XRC
| Human complement factor I | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, HUMAN COMPLEMENT FACTOR I | Authors: | Roversi, P, Johnson, S, Lea, S.M. | Deposit date: | 2010-09-13 | Release date: | 2011-07-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Structural Basis for Complement Factor I Control and its Disease-Associated Sequence Polymorphisms. Proc.Natl.Acad.Sci.USA, 108, 2011
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8OXI
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8OXH
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8OXL
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3SQH
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3TMP
| The catalytic domain of human deubiquitinase DUBA in complex with ubiquitin aldehyde | Descriptor: | OTU domain-containing protein 5, Polyubiquitin-C | Authors: | Ma, X, Yin, J, Hymowitz, S, Starovasnik, M, Cochran, A. | Deposit date: | 2011-08-31 | Release date: | 2012-01-11 | Last modified: | 2012-02-29 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Phosphorylation-dependent activity of the deubiquitinase DUBA. Nat.Struct.Mol.Biol., 19, 2012
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4AW9
| Crystal structure of active legumain in complex with YVAD-CMK | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACE-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE, LEGUMAIN, ... | Authors: | Dall, E, Brandstetter, H. | Deposit date: | 2012-06-01 | Release date: | 2013-06-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mechanistic and Structural Studies on Legumain Explain its Zymogenicity, Distinct Activation Pathways, and Regulation Proc.Natl.Acad.Sci.USA, 110, 2013
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3UW4
| Crystal structure of cIAP1 BIR3 bound to GDC0152 | Descriptor: | Baculoviral IAP repeat-containing protein 2, Baculoviral IAP repeat-containing protein 4, GDC0152, ... | Authors: | Maurer, B, Hymowitz, S. | Deposit date: | 2011-11-30 | Release date: | 2012-02-22 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152). J.Med.Chem., 55, 2012
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3TMO
| The catalytic domain of human deubiquitinase DUBA | Descriptor: | OTU domain-containing protein 5 | Authors: | Yin, J, Bosanac, I, Ma, X, Hymowitz, S, Starovasnik, M, Cochran, A. | Deposit date: | 2011-08-31 | Release date: | 2012-01-11 | Last modified: | 2012-02-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Phosphorylation-dependent activity of the deubiquitinase DUBA. Nat.Struct.Mol.Biol., 19, 2012
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4AWA
| Crystal structure of active legumain in complex with YVAD-CMK at pH 5.0 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LEGUMAIN, SULFATE ION, ... | Authors: | Dall, E, Brandstetter, H. | Deposit date: | 2012-06-01 | Release date: | 2013-06-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mechanistic and Structural Studies on Legumain Explain its Zymogenicity, Distinct Activation Pathways, and Regulation Proc.Natl.Acad.Sci.USA, 110, 2013
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