Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3MV7

Crystal Structure of the TK3 TCR in complex with HLA-B*3501/HPVG

Summary for 3MV7
Entry DOI10.2210/pdb3mv7/pdb
Related2fyy 3MV8 3MV9
DescriptorHLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, HPVG peptide from Epstein-Barr nuclear antigen 1, ... (7 entities in total)
Functional Keywordshla b*3501, ebv, tcr, tcrpmhc complex, hpvg, tcr polymorphism, immune system
Biological sourceHomo sapiens (human)
More
Cellular locationMembrane; Single-pass type I membrane protein: P30685
Secreted: P61769
Host nucleus: P03211
Total number of polymer chains5
Total formula weight94478.42
Authors
Primary citationGras, S.,Chen, Z.,Miles, J.J.,Liu, Y.C.,Bell, M.J.,Sullivan, L.C.,Kjer-Nielsen, L.,Brennan, R.M.,Burrows, J.M.,Neller, M.A.,Khanna, R.,Purcell, A.W.,Brooks, A.G.,McCluskey, J.,Rossjohn, J.,Burrows, S.R.
Allelic polymorphism in the T cell receptor and its impact on immune responses
J.Exp.Med., 207:1555-1567, 2010
Cited by
PubMed Abstract: In comparison to human leukocyte antigen (HLA) polymorphism, the impact of allelic sequence variation within T cell receptor (TCR) loci is much less understood. Particular TCR loci have been associated with autoimmunity, but the molecular basis for this phenomenon is undefined. We examined the T cell response to an HLA-B*3501-restricted epitope (HPVGEADYFEY) from Epstein-Barr virus (EBV), which is frequently dominated by a TRBV9*01(+) public TCR (TK3). However, the common allelic variant TRBV9*02, which differs by a single amino acid near the CDR2beta loop (Gln55-->His55), was never used in this response. The structure of the TK3 TCR, its allelic variant, and a nonnaturally occurring mutant (Gln55-->Ala55) in complex with HLA-B*3501(HPVGEADYFEY) revealed that the Gln55-->His55 polymorphism affected the charge complementarity at the TCR-peptide-MHC interface, resulting in reduced functional recognition of the cognate and naturally occurring variants of this EBV peptide. Thus, polymorphism in the TCR loci may contribute toward variability in immune responses and the outcome of infection.
PubMed: 20566715
DOI: 10.1084/jem.20100603
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

227561

PDB entries from 2024-11-20

PDB statisticsPDBj update infoContact PDBjnumon