3P08

Crystal structure of the human BTK kinase domain

Summary for 3P08

• Entry DOI: 10.2210/pdb3p08/pdb
• Related: 3OCS 3OCT
• Descriptor: Tyrosine-protein kinase BTK (2 entities in total)
• Functional Keywords: b-cell, alpha/beta, kinase, phosphorylation, cytosol, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q06187
• Total number of polymer chains: 2
• Total formula weight: 62415.71

Authors

Yu, C.L.,Hymowitz, S.G. (deposition date: 2010-09-27, release date: 2010-11-03, Last modification date: 2023-09-06)

• Primary citation: Di Paolo, J.,Huang, T.,Balazs, M.,Barbosa, J.,Barck, K.H.,Bravo, B.,Carano, R.A.D.,Darrow, J.,Davies, D.R.,DeForge, L.E.,Diehl, L.,Ferrando, R.,Gallion, S.L.,Gianetti, A.M.,Gribling, P.,Hurez, V.,Hymowitz, S.G.,Jones, R.,Kropf, J.E.,Lee, W.P.,Maciejewski, P.M.,Mitchell, S.A.,Rong, H.,Staker, B.L.,Whitney, J.A.,Yeh, S.,Young, W.,Yu, C.,Zhang, J.,Reif, K.,Currie, K.S.; A novel, specific BTK inhibitor antagonizes BCR and FcgR signaling and suppresses inflammatory arthritis; To be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)