3UW4

Crystal structure of cIAP1 BIR3 bound to GDC0152

Summary for 3UW4

• Entry DOI: 10.2210/pdb3uw4/pdb
• Related PRD ID: PRD_001020
• Descriptor: Baculoviral IAP repeat-containing protein 2, Baculoviral IAP repeat-containing protein 4, GDC0152, ZINC ION, ... (4 entities in total)
• Functional Keywords: apoptosis inhibitor, bir domain
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P98170
• Total number of polymer chains: 2
• Total formula weight: 11253.46

Authors

Maurer, B.,Hymowitz, S. (deposition date: 2011-11-30, release date: 2012-02-22, Last modification date: 2023-12-06)

• Primary citation: Flygare, J.A.,Beresini, M.,Budha, N.,Chan, H.,Chan, I.T.,Cheeti, S.,Cohen, F.,Deshayes, K.,Doerner, K.,Eckhardt, S.G.,Elliott, L.O.,Feng, B.,Franklin, M.C.,Reisner, S.F.,Gazzard, L.,Halladay, J.,Hymowitz, S.G.,La, H.,Lorusso, P.,Maurer, B.,Murray, L.,Plise, E.,Quan, C.,Stephan, J.P.,Young, S.G.,Tom, J.,Tsui, V.,Um, J.,Varfolomeev, E.,Vucic, D.,Wagner, A.J.,Wallweber, H.J.,Wang, L.,Ware, J.,Wen, Z.,Wong, H.,Wong, J.M.,Wong, M.,Wong, S.,Yu, R.,Zobel, K.,Fairbrother, W.J.; Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152).; J.Med.Chem., 55:4101-4113, 2012; PubMed: 22413863; DOI: 10.1021/jm300060k

Experimental method

X-RAY DIFFRACTION (1.79 Å)