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3UW4

Crystal structure of cIAP1 BIR3 bound to GDC0152

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Baculoviral IAP repeat-containing protein 2, Baculoviral IAP repeat-containing protein 4polymer9210624.01UniProt (Q13490)
UniProt (P98170)
Pfam (PF00653)
Homo sapiens (human)C-IAP1, IAP homolog B, Inhibitor of apoptosis protein 2, IAP-2, hIAP-2, hIAP2, RING finger protein 48, TNFR2-TRAF-signaling complex protein 2, E3 ubiquitin-protein ligase XIAP, IAP-like protein, ILP, hILP, Inhibitor of apoptosis protein 3, IAP-3, hIAP-3, hIAP3, X-linked inhibitor of apoptosis protein, X-linked IAP
2B
(Z)
GDC0152polymer4498.61BIRD (PRD_001020)
3C, D
(A)
ZINC IONnon-polymer65.42Chemie (ZN)
4E
(A)
waterwater18.053Chemie (HOH)
Sequence modifications
A: 252 - 329 (UniProt: Q13490)
PDBExternal DatabaseDetails
Gly 249-expression tag
Ser 250-expression tag
His 251-expression tag
Ala 278Ser 292engineered mutation
Ser 294Cys 308engineered mutation
Gly 318Arg 332engineered mutation
A: 330 - 340 (UniProt: P98170)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight11122.6
Non-Polymers*Number of molecules2
Total formula weight130.8
All*Total formula weight11253.5
*Water molecules are not included.

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PDB entries from 2025-07-09

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