3UW4
Crystal structure of cIAP1 BIR3 bound to GDC0152
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Baculoviral IAP repeat-containing protein 2, Baculoviral IAP repeat-containing protein 4 | polymer | 92 | 10624.0 | 1 | UniProt (Q13490) UniProt (P98170) Pfam (PF00653) In PDB | Homo sapiens (human) | C-IAP1, IAP homolog B, Inhibitor of apoptosis protein 2, IAP-2, hIAP-2, hIAP2, RING finger protein 48, TNFR2-TRAF-signaling complex protein 2, E3 ubiquitin-protein ligase XIAP, IAP-like protein, ILP, hILP, Inhibitor of apoptosis protein 3, IAP-3, hIAP-3, hIAP3, X-linked inhibitor of apoptosis protein, X-linked IAP |
2 | Z | GDC0152 | polymer | 4 | 498.6 | 1 | BIRD (PRD_001020) | ||
3 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
4 | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A: 252 - 329 (UniProt: Q13490)
A: 330 - 340 (UniProt: P98170)
PDB | External Database | Details |
---|---|---|
Gly 249 | - | expression tag |
Ser 250 | - | expression tag |
His 251 | - | expression tag |
Ala 278 | Ser 292 | engineered mutation |
Ser 294 | Cys 308 | engineered mutation |
Gly 318 | Arg 332 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 11122.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 130.8 | |
All* | Total formula weight | 11253.5 |