3UW4

Crystal structure of cIAP1 BIR3 bound to GDC0152

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Baculoviral IAP repeat-containing protein 2, Baculoviral IAP repeat-containing protein 4	polymer	92	10624.0	1	UniProt (Q13490) UniProt (P98170) Pfam (PF00653)	Homo sapiens (human)	C-IAP1, IAP homolog B, Inhibitor of apoptosis protein 2, IAP-2, hIAP-2, hIAP2, RING finger protein 48, TNFR2-TRAF-signaling complex protein 2, E3 ubiquitin-protein ligase XIAP, IAP-like protein, ILP, hILP, Inhibitor of apoptosis protein 3, IAP-3, hIAP-3, hIAP3, X-linked inhibitor of apoptosis protein, X-linked IAP
2	B (Z)	GDC0152	polymer	4	498.6	1	BIRD (PRD_001020)
3	C, D (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	E (A)	water	water		18.0	53	Chemie (HOH)

Sequence modifications

A: 252 - 329 (UniProt: Q13490)

PDB	External Database	Details
Gly 249	-	expression tag
Ser 250	-	expression tag
His 251	-	expression tag
Ala 278	Ser 292	engineered mutation
Ser 294	Cys 308	engineered mutation
Gly 318	Arg 332	engineered mutation

A: 330 - 340 (UniProt: P98170)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	11122.6
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	11253.5

*Water molecules are not included.