PDB: 364 resultsInfo pagesStatus searchChemie searchBIRD

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5WBU	Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex Descriptor: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 Authors: Pavletich, N.P, Yang, H. Deposit date: 2017-06-29 Release date: 2017-12-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.42 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBH	Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1 Descriptor: Ribosomal protein S6 kinase beta-1, Serine/threonine-protein kinase mTOR Authors: Pavletich, N.P, Yang, H. Deposit date: 2017-06-29 Release date: 2017-12-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBY	Crystal structure of mTOR(deltaN)-mLST8-PRAS40(beta-strand) complex Descriptor: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 Authors: Pavletich, N.P, Yang, H. Deposit date: 2017-06-29 Release date: 2017-12-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
9F42	cryo-EM structure of LST2 TOS peptide bound to human mTOR complex 1, focused on RAPTOR Descriptor: Lateral signaling target protein 2 homolog, Regulatory-associated protein of mTOR Authors: Craigie, L.M, Maier, T. Deposit date: 2024-04-26 Release date: 2024-08-14 Last modified: 2024-08-28 Method: ELECTRON MICROSCOPY (3.27 Å) Cite: mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR. Proc.Natl.Acad.Sci.USA, 121, 2024
9F43	cryo-EM structure of human LST2 bound to human mTOR complex 1, focused on RAPTOR Descriptor: Lateral signaling target protein 2 homolog, Regulatory-associated protein of mTOR Authors: Craigie, L.M, Maier, T. Deposit date: 2024-04-26 Release date: 2024-08-14 Last modified: 2024-08-28 Method: ELECTRON MICROSCOPY (3.49 Å) Cite: mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR. Proc.Natl.Acad.Sci.USA, 121, 2024
7UXH	cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... Authors: Cui, Z, Hurley, J. Deposit date: 2022-05-05 Release date: 2022-11-30 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature, 614, 2023
7UXC	cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex with symmetry expansion Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... Authors: Cui, Z, Hurley, J. Deposit date: 2022-05-05 Release date: 2022-11-30 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature, 614, 2023
7TZO	The apo structure of human mTORC2 complex Descriptor: Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... Authors: Yu, Z, Chen, J, Pearce, D. Deposit date: 2022-02-16 Release date: 2023-01-11 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.28 Å) Cite: Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt. J.Biol.Chem., 298, 2022
8RCN	CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused region of mTOR and RAPTOR on one protomer copy. Descriptor: Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Anandapadamanaban, M, Hay, I.M, Perisic, O, Williams, R.L. Deposit date: 2023-12-06 Release date: 2024-09-11 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused region of mTOR and RAPTOR on one protomer copy. To Be Published
8RCK	CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused on one protomer copy. Descriptor: Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Anandapadamanaban, M, Hay, I.M, Perisic, O, Williams, R.L. Deposit date: 2023-12-06 Release date: 2024-09-11 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused on one protomer copy. To Be Published
8RCH	CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, overall refinement Descriptor: Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Anandapadamanaban, M, Hay, I.M, Perisic, O, Williams, R.L. Deposit date: 2023-12-06 Release date: 2024-09-11 Method: ELECTRON MICROSCOPY (4 Å) Cite: cryoEM structure of mTORC1 with the cancer-associated 1455-EWED-1458 duplication variant, overall refinement To Be Published
8PPZ	Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR Descriptor: (1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-[(~{E})-2-(2-chlorophenyl)ethenyl]-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one, ACETATE ION, CALCIUM ION, ... Authors: Meyners, C, Deutscher, R.C.E, Hausch, F. Deposit date: 2023-07-10 Release date: 2023-08-09 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR Chemrxiv, 2023
6EHR	The crystal structure of the human LAMTOR-RagA CTD-RagC CTD complex Descriptor: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... Authors: Scheffzek, K, Naschberger, A. Deposit date: 2017-09-14 Release date: 2017-10-04 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.898 Å) Cite: Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling. Science, 358, 2017
6EHP	The crystal structure of the human LAMTOR complex Descriptor: CHLORIDE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... Authors: Scheffzek, K, Naschberger, A. Deposit date: 2017-09-14 Release date: 2017-10-04 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling. Science, 358, 2017
5YK5	structure of the human Lamtor4-Lamtor5 complex Descriptor: Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5 Authors: Wu, G, Mu, Z. Deposit date: 2017-10-12 Release date: 2018-12-12 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane Cell Discov, 3, 2017
7VKK	Crystal structure of D. melanogaster SAMTOR V66W/E67P mutant Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, S-adenosylmethionine sensor upstream of mTORC1, SULFATE ION Authors: Zhang, T, Ding, J. Deposit date: 2021-09-30 Release date: 2022-07-20 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.55 Å) Cite: Molecular mechanism of S -adenosylmethionine sensing by SAMTOR in mTORC1 signaling. Sci Adv, 8, 2022
7VKR	Crystal structure of D. melanogaster SAMTOR in complex with SAM Descriptor: CITRIC ACID, S-ADENOSYLMETHIONINE, S-adenosylmethionine sensor upstream of mTORC1 Authors: Tang, X, Zhang, T, Ding, J. Deposit date: 2021-09-30 Release date: 2022-07-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Molecular mechanism of S -adenosylmethionine sensing by SAMTOR in mTORC1 signaling. Sci Adv, 8, 2022
7VKQ	Crystal structure of D. melanogaster SAMTOR in the SAH bound form Descriptor: S-ADENOSYL-L-HOMOCYSTEINE, S-adenosylmethionine sensor upstream of mTORC1 Authors: Tang, X, Zhang, T, Ding, J. Deposit date: 2021-09-30 Release date: 2022-07-20 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.094 Å) Cite: Molecular mechanism of S -adenosylmethionine sensing by SAMTOR in mTORC1 signaling. Sci Adv, 8, 2022
3JBZ	Crystal structure of mTOR docked into EM map of dimeric ATM kinase Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase mTOR, ... Authors: Lau, W.C.Y. Deposit date: 2015-11-03 Release date: 2016-11-16 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (28 Å) Cite: Structure of the human dimeric ATM kinase. Cell Cycle, 15, 2016
8FW5	Chimeric HsGATOR1-SpGtr-SpLam complex Descriptor: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ... Authors: Tettoni, S.D, Egri, S.B, Doxsey, D.D, Ouch, C, Chang, J, Song, K, Xu, C, Shen, K. Deposit date: 2023-01-20 Release date: 2023-07-26 Last modified: 2023-09-20 Method: ELECTRON MICROSCOPY (3.08 Å) Cite: Structure of the Schizosaccharomyces pombe Gtr-Lam complex reveals evolutionary divergence of mTORC1-dependent amino acid sensing. Structure, 31, 2023
2GAQ	NMR SOLUTION STRUCTURE OF THE FRB DOMAIN OF mTOR Descriptor: FKBP12-rapamycin complex-associated protein Authors: Leone, M, Pellecchia, M. Deposit date: 2006-03-09 Release date: 2006-08-08 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: The FRB Domain of mTOR: NMR Solution Structure and Inhibitor Design. Biochemistry, 45, 2006
3OAW	4-Methylpteridineones as Orally Active and Selective PI3K/mTOR Dual Inhibitors Descriptor: 2-amino-4-methyl-8-(1-methylethyl)-6-(1H-pyrazol-4-yl)pteridin-7(8H)-one, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Authors: Knighton, D.R, Greasley, S.E, Rodgers, C.M.-L. Deposit date: 2010-08-05 Release date: 2010-09-22 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.75 Å) Cite: 4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
5OQ4	PQR309 - a Potent, Brain-Penetrant, Orally Bioavailable, pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology Descriptor: 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION Authors: Williams, R.L, Zhang, X. Deposit date: 2017-08-10 Release date: 2017-09-06 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.7 Å) Cite: 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology. J. Med. Chem., 60, 2017
4DRH	Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTOR at low pH Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP5, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, SULFATE ION, ... Authors: Maerz, A.M, Bracher, A, Hausch, F. Deposit date: 2012-02-17 Release date: 2013-02-06 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin. Mol.Cell.Biol., 33, 2013
2RSE	NMR structure of FKBP12-mTOR FRB domain-rapamycin complex structure determined based on PCS Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1A, Serine/threonine-protein kinase mTOR, TERBIUM(III) ION Authors: Kobashigawa, Y, Ushio, M, Saio, T, Inagaki, F. Deposit date: 2012-01-25 Release date: 2012-05-30 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Convenient method for resolving degeneracies due to symmetry of the magnetic susceptibility tensor and its application to pseudo contact shift-based protein-protein complex structure determination. J.Biomol.Nmr, 53, 2012

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