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4DRH

Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTOR at low pH

Summary for 4DRH
Entry DOI10.2210/pdb4drh/pdb
Related4DRI 4DRJ
DescriptorPeptidyl-prolyl cis-trans isomerase FKBP5, Serine/threonine-protein kinase mTOR, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, ... (5 entities in total)
Functional Keywordsfk-506 binding domain, hsp90 cochaperone, immunophilin, peptidyl-prolyl isomerase, mammalian target of rapamycin, kinase, signalling, immunosuppression, cancer, isomerase-transferase complex, isomerase/transferase
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm: Q13451
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P42345
Total number of polymer chains4
Total formula weight58728.08
Authors
Maerz, A.M.,Bracher, A.,Hausch, F. (deposition date: 2012-02-17, release date: 2013-02-06, Last modification date: 2023-09-13)
Primary citationMarz, A.M.,Fabian, A.K.,Kozany, C.,Bracher, A.,Hausch, F.
Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin.
Mol.Cell.Biol., 33:1357-1367, 2013
Cited by
PubMed: 23358420
DOI: 10.1128/MCB.00678-12
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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