4DRH
Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTOR at low pH
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | Peptidyl-prolyl cis-trans isomerase FKBP5 | polymer | 144 | 15693.8 | 2 | UniProt (Q13451) Pfam (PF00254) In PDB | Homo sapiens (human) | PPIase FKBP5, 51 kDa FK506-binding protein, 51 kDa FKBP, FKBP-51, 54 kDa progesterone receptor-associated immunophilin, Androgen-regulated protein 6, FF1 antigen, FK506-binding protein 5, FKBP-5, FKBP54, p54, HSP90-binding immunophilin, Rotamase |
2 | B, E | Serine/threonine-protein kinase mTOR | polymer | 98 | 11747.4 | 2 | UniProt (P42345) Pfam (PF08771) In PDB | Homo sapiens (human) | FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, mTOR, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1 |
3 | A, D | RAPAMYCIN IMMUNOSUPPRESSANT DRUG | non-polymer | 914.2 | 2 | Chemie (RAP) | |||
4 | E, A, B, D | SULFATE ION | non-polymer | 96.1 | 21 | Chemie (SO4) | |||
5 | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 140 (UniProt: Q13451)
B, E: 2025 - 2114 (UniProt: P42345)
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Ala -2 | - | expression tag |
Met -1 | - | expression tag |
Gly 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 2017 | - | expression tag |
Ala 2018 | - | expression tag |
Met 2019 | - | expression tag |
Asp 2020 | - | expression tag |
Pro 2021 | - | expression tag |
Glu 2022 | - | expression tag |
Phe 2023 | - | expression tag |
Met 2024 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 54882.4 | |
Non-Polymers* | Number of molecules | 23 |
Total formula weight | 3845.7 | |
All* | Total formula weight | 58728.1 |