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5WBU

Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex

Summary for 5WBU
Entry DOI10.2210/pdb5wbu/pdb
DescriptorSerine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Proline-rich AKT1 substrate 1 (3 entities in total)
Functional Keywordscomplex, frb, wd40, pras40, transferase
Biological sourceHomo sapiens (Human)
More
Cellular locationEndoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P42345
Cytoplasm : Q9BVC4
Cytoplasm, cytosol : Q96B36
Total number of polymer chains8
Total formula weight381231.46
Authors
Pavletich, N.P.,Yang, H. (deposition date: 2017-06-29, release date: 2017-12-20, Last modification date: 2023-10-04)
Primary citationYang, H.,Jiang, X.,Li, B.,Yang, H.J.,Miller, M.,Yang, A.,Dhar, A.,Pavletich, N.P.
Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552:368-373, 2017
Cited by
PubMed: 29236692
DOI: 10.1038/nature25023
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.42 Å)
Structure validation

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