8RCN

CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused region of mTOR and RAPTOR on one protomer copy.

Summary for 8RCN

• Entry DOI: 10.2210/pdb8rcn/pdb
• EMDB information: 19056
• Descriptor: Serine/threonine-protein kinase mTOR, Regulatory-associated protein of mTOR, Eukaryotic translation initiation factor 4E-binding protein 1, ... (5 entities in total)
• Functional Keywords: target of rapamycin, mtor, cancer-associated mutants, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 451605.76

Authors

Anandapadamanaban, M.,Hay, I.M.,Perisic, O.,Williams, R.L. (deposition date: 2023-12-06, release date: 2024-09-11)

• Primary citation: Anandapadamanaban, M.,Hay, I.M.,Perisic, O.,Williams, R.L.; CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused region of mTOR and RAPTOR on one protomer copy.; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.1 Å)