8RCH

CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, overall refinement

Summary for 8RCH

• Entry DOI: 10.2210/pdb8rch/pdb
• EMDB information: 19052 19056
• Descriptor: Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Regulatory-associated protein of mTOR, ... (6 entities in total)
• Functional Keywords: target of rapamycin, mtor, cancer-associated mutants, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 975031.70

Authors

Anandapadamanaban, M.,Hay, I.M.,Perisic, O.,Williams, R.L. (deposition date: 2023-12-06, release date: 2024-09-11)

• Primary citation: Anandapadamanaban, M.,Hay, I.,Perisic, O.,Williams, R.; cryoEM structure of mTORC1 with the cancer-associated 1455-EWED-1458 duplication variant, overall refinement; To Be Published,

Experimental method

ELECTRON MICROSCOPY (4 Å)