8RCH

CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, overall refinement

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Serine/threonine-protein kinase mTOR	polymer	2549	289258.0	2	UniProt (P42345) In PDB	Homo sapiens (human)	FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1
2	D, E	Target of rapamycin complex subunit LST8	polymer	326	35910.1	2	UniProt (Q9BVC4) In PDB	Homo sapiens (human)	TORC subunit LST8,G protein beta subunit-like,Protein GbetaL,Mammalian lethal with SEC13 protein 8,mLST8
3	W, Y	Regulatory-associated protein of mTOR	polymer	1335	149200.0	2	UniProt (Q8N122) In PDB	Homo sapiens (human)	Raptor,p150 target of rapamycin (TOR)-scaffold protein
4	Z, X	Eukaryotic translation initiation factor 4E-binding protein 1	polymer	118	12593.0	2	UniProt (Q13541) In PDB	Homo sapiens (human)	4E-BP1,eIF4E-binding protein 1,Phosphorylated heat- and acid-stable protein regulated by insulin 1,PHAS-I
5	A, B	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	2	Chemie (ANP)
6	A, B	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	973922.1
Non-Polymers*	Number of molecules	6
	Total formula weight	1109.6
All*	Total formula weight	975031.7

*Water molecules are not included.