8RCH
CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, overall refinement
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, B) | Serine/threonine-protein kinase mTOR | polymer | 2549 | 289258.0 | 2 | UniProt (P42345) Pfam (PF11865) Pfam (PF02259) Pfam (PF23593) Pfam (PF08771) Pfam (PF00454) Pfam (PF02260) | Homo sapiens (human) | FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1 |
| 2 | B, F (D, E) | Target of rapamycin complex subunit LST8 | polymer | 326 | 35910.1 | 2 | UniProt (Q9BVC4) Pfam (PF00400) | Homo sapiens (human) | TORC subunit LST8,G protein beta subunit-like,Protein GbetaL,Mammalian lethal with SEC13 protein 8,mLST8 |
| 3 | C, G (W, Y) | Regulatory-associated protein of mTOR | polymer | 1335 | 149200.0 | 2 | UniProt (Q8N122) Pfam (PF14538) Pfam (PF02985) Pfam (PF00400) | Homo sapiens (human) | Raptor,p150 target of rapamycin (TOR)-scaffold protein |
| 4 | D, H (Z, X) | Eukaryotic translation initiation factor 4E-binding protein 1 | polymer | 118 | 12593.0 | 2 | UniProt (Q13541) Pfam (PF05456) | Homo sapiens (human) | 4E-BP1,eIF4E-binding protein 1,Phosphorylated heat- and acid-stable protein regulated by insulin 1,PHAS-I |
| 5 | I, L (A, B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 6 | J, K, M, N (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 973922.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1109.6 | |
| All* | Total formula weight | 975031.7 |
