7TZO

The apo structure of human mTORC2 complex

Summary for 7TZO

• Entry DOI: 10.2210/pdb7tzo/pdb
• EMDB information: 26213
• Descriptor: Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Rapamycin-insensitive companion of mTOR, ... (4 entities in total)
• Functional Keywords: complex, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 1189814.63

Authors

Yu, Z.,Chen, J.,Pearce, D. (deposition date: 2022-02-16, release date: 2023-01-11)

• Primary citation: Yu, Z.,Chen, J.,Takagi, E.,Wang, F.,Saha, B.,Liu, X.,Joubert, L.M.,Gleason, C.E.,Jin, M.,Li, C.,Nowotny, C.,Agard, D.,Cheng, Y.,Pearce, D.; Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.; J.Biol.Chem., 298:102288-102288, 2022; PubMed: 35926713; DOI: 10.1016/j.jbc.2022.102288

Experimental method

ELECTRON MICROSCOPY (3.28 Å)