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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7TZO

The apo structure of human mTORC2 complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)		Serine/threonine-protein kinase mTORpolymer2674302330.42UniProt (P42345)
Pfam (PF11865)
Pfam (PF02259)
Pfam (PF23593)
Pfam (PF08771)
Pfam (PF00454)
Pfam (PF02260)		Homo sapiens (human)FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1
2C, D
(C, D)		Target of rapamycin complex subunit LST8polymer34737998.32UniProt (Q9BVC4)
Pfam (PF00400)		Homo sapiens (human)TORC subunit LST8,G protein beta subunit-like,Gable,Protein GbetaL,Mammalian lethal with SEC13 protein 8,mLST8
3E, F
(E, F)		Rapamycin-insensitive companion of mTORpolymer1720193846.32UniProt (Q6R327)
Pfam (PF14664)
Pfam (PF14666)
Pfam (PF14663)
Pfam (PF14668)
Pfam (PF14665)		Homo sapiens (human)AVO3 homolog,hAVO3
4G, H
(G, H)		Target of rapamycin complex 2 subunit MAPKAP1polymer53860732.32UniProt (Q9BPZ7)
Pfam (PF05422)
Pfam (PF16978)
Pfam (PF25322)
Pfam (PF16979)		Homo sapiens (human)TORC2 subunit MAPKAP1,Mitogen-activated protein kinase 2-associated protein 1,Stress-activated map kinase-interacting protein 1,SAPK-interacting protein 1,mSIN1
Sequence modifications
A, B: 1 - 2549 (UniProt: P42345)
PDBExternal DatabaseDetails
Met -124-initiating methionine
Val -123-expression tag
Thr -122-expression tag
Thr -121-expression tag
Leu -120-expression tag
Ser -119-expression tag
Gly -118-expression tag
Leu -117-expression tag
Ser -116-expression tag
Gly -115-expression tag
Glu -114-expression tag
Gln -113-expression tag
Gly -112-expression tag
Pro -111-expression tag
Ser -110-expression tag
Gly -109-expression tag
Asp -108-expression tag
Met -107-expression tag
Thr -106-expression tag
Thr -105-expression tag
Glu -104-expression tag
Glu -103-expression tag
Asp -102-expression tag
Ser -101-expression tag
Ala -100-expression tag
Thr -99-expression tag
His -98-expression tag
Ile -97-expression tag
Lys -96-expression tag
Phe -95-expression tag
Ser -94-expression tag
Lys -93-expression tag
Arg -92-expression tag
Asp -91-expression tag
Glu -90-expression tag
Asp -89-expression tag
Gly -88-expression tag
Arg -87-expression tag
Glu -86-expression tag
Leu -85-expression tag
Ala -84-expression tag
Gly -83-expression tag
Ala -82-expression tag
Thr -81-expression tag
Met -80-expression tag
Glu -79-expression tag
Leu -78-expression tag
Arg -77-expression tag
Asp -76-expression tag
Ser -75-expression tag
Ser -74-expression tag
Gly -73-expression tag
Lys -72-expression tag
Thr -71-expression tag
Ile -70-expression tag
Ser -69-expression tag
Thr -68-expression tag
Trp -67-expression tag
Ile -66-expression tag
Ser -65-expression tag
Asp -64-expression tag
Gly -63-expression tag
His -62-expression tag
Val -61-expression tag
Lys -60-expression tag
Asp -59-expression tag
Phe -58-expression tag
Tyr -57-expression tag
Leu -56-expression tag
Tyr -55-expression tag
Pro -54-expression tag
Gly -53-expression tag
Lys -52-expression tag
Tyr -51-expression tag
Thr -50-expression tag
Phe -49-expression tag
Val -48-expression tag
Glu -47-expression tag
Thr -46-expression tag
Ala -45-expression tag
Ala -44-expression tag
Pro -43-expression tag
Asp -42-expression tag
Gly -41-expression tag
Tyr -40-expression tag
Glu -39-expression tag
Val -38-expression tag
Ala -37-expression tag
Thr -36-expression tag
Pro -35-expression tag
Ile -34-expression tag
Glu -33-expression tag
Phe -32-expression tag
Thr -31-expression tag
Val -30-expression tag
Asn -29-expression tag
Glu -28-expression tag
Asp -27-expression tag
Gly -26-expression tag
Gln -25-expression tag
Val -24-expression tag
Thr -23-expression tag
Val -22-expression tag
Asp -21-expression tag
Gly -20-expression tag
Glu -19-expression tag
Ala -18-expression tag
Thr -17-expression tag
Glu -16-expression tag
Gly -15-expression tag
Asp -14-expression tag
Ala -13-expression tag
His -12-expression tag
Thr -11-expression tag
Gly -10-expression tag
Ser -9-expression tag
Ser -8-expression tag
Gly -7-expression tag
Ser -6-expression tag
Gly -5-expression tag
Ser -4-expression tag
Gly -3-expression tag
Thr -2-expression tag
Gly -1-expression tag
Ser 0-expression tag
C, D: 1 - 326 (UniProt: Q9BVC4)
PDBExternal DatabaseDetails
Met -20-initiating methionine
Gly -19-expression tag
Tyr -18-expression tag
Pro -17-expression tag
Tyr -16-expression tag
Asp -15-expression tag
Val -14-expression tag
Pro -13-expression tag
Asp -12-expression tag
Tyr -11-expression tag
Ala -10-expression tag
Asp -9-expression tag
Leu -8-expression tag
Asn -7-expression tag
Gly -6-expression tag
Gly -5-expression tag
Gly -4-expression tag
Gly -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Thr 0-expression tag
E, F: 1 - 1708 (UniProt: Q6R327)
PDBExternal DatabaseDetails
Met -11-initiating methionine
Asp -10-expression tag
Tyr -9-expression tag
Lys -8-expression tag
Asp -7-expression tag
Asp -6-expression tag
Asp -5-expression tag
Asp -4-expression tag
Lys -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Thr 0-expression tag
G, H: 1 - 522 (UniProt: Q9BPZ7)
PDBExternal DatabaseDetails
Ala 523-expression tag
Ala 524-expression tag
Ala 525-expression tag
Gly 526-expression tag
Gly 527-expression tag
Gly 528-expression tag
Gly 529-expression tag
Tyr 530-expression tag
Pro 531-expression tag
Tyr 532-expression tag
Asp 533-expression tag
Val 534-expression tag
Pro 535-expression tag
Asp 536-expression tag
Tyr 537-expression tag
Ala 538-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains8
Total formula weight1189814.6
All*Total formula weight1189814.6
*Water molecules are not included.

248335

PDB entries from 2026-01-28

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