7TZO
The apo structure of human mTORC2 complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Serine/threonine-protein kinase mTOR | polymer | 2674 | 302330.4 | 2 | UniProt (P42345) Pfam (PF11865) Pfam (PF02259) Pfam (PF08771) Pfam (PF00454) Pfam (PF02260) In PDB | Homo sapiens (human) | FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1 |
2 | C, D | Target of rapamycin complex subunit LST8 | polymer | 347 | 37998.3 | 2 | UniProt (Q9BVC4) Pfam (PF00400) In PDB | Homo sapiens (human) | TORC subunit LST8,G protein beta subunit-like,Gable,Protein GbetaL,Mammalian lethal with SEC13 protein 8,mLST8 |
3 | E, F | Rapamycin-insensitive companion of mTOR | polymer | 1720 | 193846.3 | 2 | UniProt (Q6R327) Pfam (PF14664) Pfam (PF14666) Pfam (PF14663) Pfam (PF14668) Pfam (PF14665) In PDB | Homo sapiens (human) | AVO3 homolog,hAVO3 |
4 | G, H | Target of rapamycin complex 2 subunit MAPKAP1 | polymer | 538 | 60732.3 | 2 | UniProt (Q9BPZ7) Pfam (PF05422) Pfam (PF16978) Pfam (PF16979) In PDB | Homo sapiens (human) | TORC2 subunit MAPKAP1,Mitogen-activated protein kinase 2-associated protein 1,Stress-activated map kinase-interacting protein 1,SAPK-interacting protein 1,mSIN1 |
Sequence modifications
A, B: 1 - 2549 (UniProt: P42345)
C, D: 1 - 326 (UniProt: Q9BVC4)
E, F: 1 - 1708 (UniProt: Q6R327)
G, H: 1 - 522 (UniProt: Q9BPZ7)
PDB | External Database | Details |
---|---|---|
Met -124 | - | initiating methionine |
Val -123 | - | expression tag |
Thr -122 | - | expression tag |
Thr -121 | - | expression tag |
Leu -120 | - | expression tag |
Ser -119 | - | expression tag |
Gly -118 | - | expression tag |
Leu -117 | - | expression tag |
Ser -116 | - | expression tag |
Gly -115 | - | expression tag |
Glu -114 | - | expression tag |
Gln -113 | - | expression tag |
Gly -112 | - | expression tag |
Pro -111 | - | expression tag |
Ser -110 | - | expression tag |
Gly -109 | - | expression tag |
Asp -108 | - | expression tag |
Met -107 | - | expression tag |
Thr -106 | - | expression tag |
Thr -105 | - | expression tag |
Glu -104 | - | expression tag |
Glu -103 | - | expression tag |
Asp -102 | - | expression tag |
Ser -101 | - | expression tag |
Ala -100 | - | expression tag |
Thr -99 | - | expression tag |
His -98 | - | expression tag |
Ile -97 | - | expression tag |
Lys -96 | - | expression tag |
Phe -95 | - | expression tag |
Ser -94 | - | expression tag |
Lys -93 | - | expression tag |
Arg -92 | - | expression tag |
Asp -91 | - | expression tag |
Glu -90 | - | expression tag |
Asp -89 | - | expression tag |
Gly -88 | - | expression tag |
Arg -87 | - | expression tag |
Glu -86 | - | expression tag |
Leu -85 | - | expression tag |
Ala -84 | - | expression tag |
Gly -83 | - | expression tag |
Ala -82 | - | expression tag |
Thr -81 | - | expression tag |
Met -80 | - | expression tag |
Glu -79 | - | expression tag |
Leu -78 | - | expression tag |
Arg -77 | - | expression tag |
Asp -76 | - | expression tag |
Ser -75 | - | expression tag |
Ser -74 | - | expression tag |
Gly -73 | - | expression tag |
Lys -72 | - | expression tag |
Thr -71 | - | expression tag |
Ile -70 | - | expression tag |
Ser -69 | - | expression tag |
Thr -68 | - | expression tag |
Trp -67 | - | expression tag |
Ile -66 | - | expression tag |
Ser -65 | - | expression tag |
Asp -64 | - | expression tag |
Gly -63 | - | expression tag |
His -62 | - | expression tag |
Val -61 | - | expression tag |
Lys -60 | - | expression tag |
Asp -59 | - | expression tag |
Phe -58 | - | expression tag |
Tyr -57 | - | expression tag |
Leu -56 | - | expression tag |
Tyr -55 | - | expression tag |
Pro -54 | - | expression tag |
Gly -53 | - | expression tag |
Lys -52 | - | expression tag |
Tyr -51 | - | expression tag |
Thr -50 | - | expression tag |
Phe -49 | - | expression tag |
Val -48 | - | expression tag |
Glu -47 | - | expression tag |
Thr -46 | - | expression tag |
Ala -45 | - | expression tag |
Ala -44 | - | expression tag |
Pro -43 | - | expression tag |
Asp -42 | - | expression tag |
Gly -41 | - | expression tag |
Tyr -40 | - | expression tag |
Glu -39 | - | expression tag |
Val -38 | - | expression tag |
Ala -37 | - | expression tag |
Thr -36 | - | expression tag |
Pro -35 | - | expression tag |
Ile -34 | - | expression tag |
Glu -33 | - | expression tag |
Phe -32 | - | expression tag |
Thr -31 | - | expression tag |
Val -30 | - | expression tag |
Asn -29 | - | expression tag |
Glu -28 | - | expression tag |
Asp -27 | - | expression tag |
Gly -26 | - | expression tag |
Gln -25 | - | expression tag |
Val -24 | - | expression tag |
Thr -23 | - | expression tag |
Val -22 | - | expression tag |
Asp -21 | - | expression tag |
Gly -20 | - | expression tag |
Glu -19 | - | expression tag |
Ala -18 | - | expression tag |
Thr -17 | - | expression tag |
Glu -16 | - | expression tag |
Gly -15 | - | expression tag |
Asp -14 | - | expression tag |
Ala -13 | - | expression tag |
His -12 | - | expression tag |
Thr -11 | - | expression tag |
Gly -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Ser -6 | - | expression tag |
Gly -5 | - | expression tag |
Ser -4 | - | expression tag |
Gly -3 | - | expression tag |
Thr -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -20 | - | initiating methionine |
Gly -19 | - | expression tag |
Tyr -18 | - | expression tag |
Pro -17 | - | expression tag |
Tyr -16 | - | expression tag |
Asp -15 | - | expression tag |
Val -14 | - | expression tag |
Pro -13 | - | expression tag |
Asp -12 | - | expression tag |
Tyr -11 | - | expression tag |
Ala -10 | - | expression tag |
Asp -9 | - | expression tag |
Leu -8 | - | expression tag |
Asn -7 | - | expression tag |
Gly -6 | - | expression tag |
Gly -5 | - | expression tag |
Gly -4 | - | expression tag |
Gly -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Thr 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Asp -10 | - | expression tag |
Tyr -9 | - | expression tag |
Lys -8 | - | expression tag |
Asp -7 | - | expression tag |
Asp -6 | - | expression tag |
Asp -5 | - | expression tag |
Asp -4 | - | expression tag |
Lys -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Thr 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ala 523 | - | expression tag |
Ala 524 | - | expression tag |
Ala 525 | - | expression tag |
Gly 526 | - | expression tag |
Gly 527 | - | expression tag |
Gly 528 | - | expression tag |
Gly 529 | - | expression tag |
Tyr 530 | - | expression tag |
Pro 531 | - | expression tag |
Tyr 532 | - | expression tag |
Asp 533 | - | expression tag |
Val 534 | - | expression tag |
Pro 535 | - | expression tag |
Asp 536 | - | expression tag |
Tyr 537 | - | expression tag |
Ala 538 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 1189814.6 | |
All* | Total formula weight | 1189814.6 |