PDB: 35 件ウェブページステータス検索Chemie searchBIRD

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7YRU	ALK2 antibody complex 分子名称: Activin receptor type-1, antibody heavy chain, antibody light chain 著者 Kawaguchi, Y, Nakamura, K, Suzuki, M, Tsuji, S, Katagiri, T. 登録日 2022-08-10 公開日 2023-05-17 最終更新日 2023-06-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A blocking monoclonal antibody reveals dimerization of intracellular domains of ALK2 associated with genetic disorders. Nat Commun, 14, 2023
1BTE	CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE TYPE II ACTIVIN RECEPTOR 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (ACTIVIN RECEPTOR TYPE II) 著者 Greenwald, J, Fischer, W, Vale, W, Choe, S. 登録日 1998-09-01 公開日 1999-02-09 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase. Nat.Struct.Biol., 6, 1999
3NH7	Crystal structure of the neutralizing Fab fragment AbD1556 bound to the BMP type I receptor IA 分子名称: Antibody fragment Fab AbD1556, heavy chain, light chain, ... 著者 Mueller, T.D, Harth, S, Sebald, W. 登録日 2010-06-14 公開日 2010-10-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity Plos One, 5, 2010
5NGV	CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, ORTHORHOMBIC CRYSTAL FORM 分子名称: Activin receptor type-2B, TETRAETHYLENE GLYCOL, anti-human ActRIIB mAb BYM338 heavy-chain, ... 著者 Rondeau, J.-M, Lehmann, S. 登録日 2017-03-20 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NH3	CRYSTAL STRUCTURE OF THE Activin receptor type-2A LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2A, ... 著者 Scheufler, C. 登録日 2017-03-21 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NHR	CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, CUBIC CRYSTAL FORM 分子名称: Activin receptor type-2B, Bimagrumab Fv Light-Chain, Bimagrumab Fv heavy-chain 著者 Rondeau, J.-M. 登録日 2017-03-22 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
2HLQ	Crystal Structure of the Extracellular Domain of the Type II BMP Receptor 分子名称: Bone morphogenetic protein receptor type-2 著者 Mace, P.D, Cutfield, J.F, Cutfield, S.M. 登録日 2006-07-09 公開日 2006-11-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: Implications for ligand binding Biochem.Biophys.Res.Commun., 351, 2006
2HLR	Crystal Structure of the Extracellular Domain of the Type II BMP Receptor 分子名称: Bone morphogenetic protein receptor type-2 著者 Mace, P.D, Cutfield, J.F, Cutfield, S.M. 登録日 2006-07-10 公開日 2006-11-28 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: Implications for ligand binding Biochem.Biophys.Res.Commun., 351, 2006
2K3G	NMR structure analysis of a BMP receptor 分子名称: Bone morphogenetic protein receptor type-1A 著者 Klages, J, Kotzsch, A, Mueller, T, Kessler, H. 登録日 2008-05-07 公開日 2008-12-16 最終更新日 2021-10-20 実験手法 SOLUTION NMR 主引用文献 The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding. Biochemistry, 47, 2008
2L5S	Solution structure of the extracellular domain of the TGF-beta type I receptor 分子名称: TGF-beta receptor type-1 著者 Zuniga, J.E, Ilangovan, U, Pardeep, M, Hinck, C, Huang, T. 登録日 2010-11-04 公開日 2011-10-26 実験手法 SOLUTION NMR 主引用文献 The TbetaR-I Pre-Helix Extension Is Structurally Ordered in the Unbound Form and Its Flanking Prolines Are Essential for Binding J.Mol.Biol., 412, 2011
1ES7	COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS 分子名称: BONE MORPHOGENETIC PROTEIN RECEPTOR IA, BONE MORPHOGENETIC PROTEIN-2 著者 Kirsch, T, Sebald, W, Dreyer, M.K. 登録日 2000-04-07 公開日 2000-10-07 最終更新日 2018-04-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of the BMP-2-BRIA ectodomain complex. Nat.Struct.Biol., 7, 2000
3KFD	Ternary complex of TGF-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily 分子名称: TGF-beta receptor type-1, TGF-beta receptor type-2, Transforming growth factor beta-1 著者 Radaev, S, Sun, P.D. 登録日 2009-10-27 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.995 Å) 主引用文献 Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily. J.Biol.Chem., 285, 2010
7MRZ	Structure of GDF11 bound to fused ActRIIB-ECD and Alk4-ECD with Anti-ActRIIB Fab fragment 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2B,Activin receptor type-1B, Fab Heavy Chain, ... 著者 Goebel, E.J, Kattamuri, C, Gipson, G.R, Thompson, T.B. 登録日 2021-05-10 公開日 2022-01-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structures of activin ligand traps using natural sets of type I and type II TGF beta receptors. Iscience, 25, 2022
6MAC	Ternary structure of GDF11 bound to ActRIIB-ECD and Alk5-ECD 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2B, Growth/differentiation factor 11, ... 著者 Goebel, E.J, Thompson, T.B. 登録日 2018-08-27 公開日 2019-07-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity. Proc.Natl.Acad.Sci.USA, 116, 2019
3EVS	Crystal structure of the GDF-5:BMP receptor IB complex. 分子名称: Bone morphogenetic protein receptor type-1B, Growth/differentiation factor 5 著者 Kotzsch, A, Mueller, T.D. 登録日 2008-10-13 公開日 2009-03-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity. Embo J., 28, 2009
1LX5	Crystal Structure of the BMP7/ActRII Extracellular Domain Complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin Type II Receptor, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-4)][alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Greenwald, J, Groppe, J, Kwiatkowski, W, Choe, S. 登録日 2002-06-04 公開日 2003-04-01 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 The BMP7/ActRII Extracellular Domain Complex Provides New Insights into the Cooperative Nature of Receptor Assembly Mol.Cell, 11, 2003
4FAO	Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2B, Growth/differentiation factor 2, ... 著者 Townson, S.A, Martinez-Hackert, E, Greppi, C, Lowden, P, Sako, D, Liu, J, Ucran, J.A, Liharska, K, Underwood, K.W, Seehra, J, Kumar, R, Grinberg, A.V. 登録日 2012-05-22 公開日 2012-06-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.357 Å) 主引用文献 Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex. J.Biol.Chem., 287, 2012
7U5O	CRYSTAL STRUCTURE OF THE BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE 2 LIGAND BINDING DOMAIN IN COMPLEX WITH ACTIVIN-B 分子名称: Bone morphogenetic protein receptor type-2, Inhibin beta B chain 著者 Chu, K.Y, Malik, A, Thamilselvan, V, Martinez-Hackert, E. 登録日 2022-03-02 公開日 2022-06-22 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition. J.Biol.Chem., 298, 2022
7U5P	CRYSTAL STRUCTURE OF THE ACTIVIN RECEPTOR TYPE-2A LIGAND BINDING DOMAIN IN COMPLEX WITH ACTIVIN-A 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2A, Inhibin beta A chain 著者 Chu, K.Y, Malik, A, Thamilselvan, V, Martinez-Hackert, E. 登録日 2022-03-02 公開日 2022-06-22 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition. J.Biol.Chem., 298, 2022
3QB4	Crystal structure of a TGF-beta ligand-receptor complex 分子名称: Bone morphogenetic protein receptor type-1A, Growth/differentiation factor 5 著者 Mueller, T.D, Nickel, J, Sebald, W. 登録日 2011-01-12 公開日 2012-03-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 GDF-5 can act as a context-dependent BMP-2 antagonist. Bmc Biol., 13, 2015
1NYU	Crystal Structure of Activin A Bound to the ECD of ActRIIB 分子名称: Inhibin beta A chain, activin receptor 著者 Thompson, T.B, Woodruff, T.K, Jardetzky, T.S. 登録日 2003-02-13 公開日 2003-04-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions EMBO J., 22, 2003
1NYS	Crystal Structure of Activin A Bound to the ECD of ActRIIB P41 分子名称: Inhibin beta A chain, activin receptor 著者 Thompson, T.B, Woodruff, T.K, Jardetzky, T.S. 登録日 2003-02-13 公開日 2003-04-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions EMBO J., 22, 2003
7OLY	Structure of activin A in complex with an ActRIIB-Alk4 fusion reveal insight into activin receptor interactions 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-1B, ... 著者 Hakansson, M, Rose, N.C, Castonguay, R, Logan, D.T, Krishnan, L. 登録日 2021-05-20 公開日 2022-02-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.265 Å) 主引用文献 Structures of activin ligand traps using natural sets of type I and type II TGF beta receptors. Iscience, 25, 2022
2PJY	Structural basis for cooperative assembly of the TGF-beta signaling complex 分子名称: TGF-beta receptor type-1, TGF-beta receptor type-2, Transforming growth factor beta-3 著者 Groppe, J, Zubieta, C. 登録日 2007-04-16 公開日 2008-02-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Mol.Cell, 29, 2008
7PPA	High resolution structure of bone morphogenetic protein receptor type II (BMPRII) extracellular domain in complex with BMP10 分子名称: Bone morphogenetic protein 10, Bone morphogenetic protein receptor type-2, GLYCEROL 著者 Guo, J, Yu, M, Read, R.J, Li, W. 登録日 2021-09-13 公開日 2022-05-11 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun, 13, 2022

 

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