1NYS

Crystal Structure of Activin A Bound to the ECD of ActRIIB P41

Summary for 1NYS

Related1NYU
Descriptoractivin receptor, Inhibin beta A chain (2 entities in total)
Functional Keywordsactivin, type ii, tgf beta, actriib, extracellular domain, membrane protein-hormone-growth factor complex, membrane protein/hormone/growth factor
Biological sourceRattus norvegicus (Norway rat)
More
Cellular locationMembrane; Single-pass type I membrane protein P38444
Secreted P08476
Total number of polymer chains4
Total molecular weight50666.92
Authors
Thompson, T.B.,Woodruff, T.K.,Jardetzky, T.S. (deposition date: 2003-02-13, release date: 2003-04-08, Last modification date: 2017-10-11)
Primary citation
Thompson, T.B.,Woodruff, T.K.,Jardetzky, T.S.
Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions
EMBO J., 22:1555-1566, 2003
PubMed: 12660162 (PDB entries with the same primary citation)
DOI: 10.1093/emboj/cdg156
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.05 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.29028 4.3% 9.4% 1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171916
PDB entries from 2020-12-02