1NYU

Crystal Structure of Activin A Bound to the ECD of ActRIIB

Summary for 1NYU

• Entry DOI: 10.2210/pdb1nyu/pdb
• Related: 1NYS
• Descriptor: activin receptor, Inhibin beta A chain (2 entities in total)
• Functional Keywords: activin, type ii, tgf beta, actriib, extracellular domain, membrane protein-hormone-growth factor complex, membrane protein/hormone/growth factor
• Biological source: Rattus norvegicus (Norway rat); More
• Cellular location: Cell membrane ; Single-pass type I membrane protein : P38445; Secreted: P08476
• Total number of polymer chains: 4
• Total formula weight: 50666.92

Authors

Thompson, T.B.,Woodruff, T.K.,Jardetzky, T.S. (deposition date: 2003-02-13, release date: 2003-04-08, Last modification date: 2023-08-16)

• Primary citation: Thompson, T.B.,Woodruff, T.K.,Jardetzky, T.S.; Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions; EMBO J., 22:1555-1566, 2003; PubMed: 12660162; DOI: 10.1093/emboj/cdg156

Experimental method

X-RAY DIFFRACTION (3.1 Å)