PDB: 142 件ウェブページステータス検索Chemie searchBIRD

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1BMP	BONE MORPHOGENETIC PROTEIN-7 分子名称: BONE MORPHOGENETIC PROTEIN-7 著者 Griffith, D.L, Scott, D.L. 登録日 1995-12-14 公開日 1997-07-23 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily. Proc.Natl.Acad.Sci.USA, 93, 1996
8V52	Crystal structure of 2A10 Fab bound to Human TGF-beta3 分子名称: 2A10 Fab Heavy Chain, 2A10 Fab Light chain, Transforming growth factor beta-3 著者 Yin, J, Lupardus, P.J. 登録日 2023-11-30 公開日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Isoform-selective TGF-beta 3 inhibition for systemic sclerosis. Med, 5, 2024
7L0J	Structure of AMH bound to AMHR2-ECD 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-Muellerian hormone type-2 receptor, Muellerian-inhibiting factor, ... 著者 Hart, K.N, Thompson, T.B. 登録日 2020-12-11 公開日 2021-06-23 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-beta family. Proc.Natl.Acad.Sci.USA, 118, 2021
6I9J	Human transforming growth factor beta2 in a tetragonal crystal form 分子名称: Transforming growth factor beta-2 proprotein 著者 Gomis-Ruth, F.X, Marino-Puertas, L, del Amo-Maestro, L, Goulas, T. 登録日 2018-11-23 公開日 2019-07-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor beta 2 in a new conformation. Sci Rep, 9, 2019
5JI1	Crystal Structure of GDF8 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Growth/differentiation factor 8 著者 Walker, R.G, Thompson, T.B. 登録日 2016-04-21 公開日 2017-03-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural basis for potency differences between GDF8 and GDF11. BMC Biol., 15, 2017
1WAQ	Crystal structure of human Growth and Differentiation Factor 5 (GDF-5) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, GROWTH/DIFFERENTIATION FACTOR 5 著者 Mueller, T.D, Nickel, J, Sebald, W. 登録日 2004-10-27 公開日 2005-05-19 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 A Single Residue of Gdf-5 Defines Binding Specificity to Bmp Receptor Ib. J.Mol.Biol., 349, 2005
1AGQ	GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT 分子名称: GLIAL CELL-DERIVED NEUROTROPHIC FACTOR 著者 Eigenbrot, C, Gerber, N. 登録日 1997-03-25 公開日 1997-06-05 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding. Nat.Struct.Biol., 4, 1997
4KV5	scFv GC1009 in complex with TGF-beta1. 分子名称: Single-chain variable fragment GC1009, Transforming growth factor beta-1 proprotein 著者 Wei, R, Moulin, A.G, Mathieu, M. 登録日 2013-05-22 公開日 2014-09-24 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions. Protein Sci., 23, 2014
1ZKZ	Crystal Structure of BMP9 分子名称: Growth/differentiation factor 2 著者 Brown, M.A, Zhao, Q, Baker, K.A, Naik, C, Chen, C, Pukac, L, Singh, M, Tsareva, T, Parice, Y, Mahoney, A, Roschke, V, Sanyal, I, Choe, S. 登録日 2005-05-04 公開日 2005-05-24 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Crystal structure of BMP-9 and functional interactions with pro-region and receptors J.Biol.Chem., 280, 2005
4KXZ	crystal structure of tgfb2 in complex with GC2008. 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, GC1008 Heavy Chain, ... 著者 Mathieu, M, Moulin, A.G, Wei, R. 登録日 2013-05-28 公開日 2014-09-24 最終更新日 2014-12-03 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions. Protein Sci., 23, 2014
4MID	Crystal Structure of Activin A/BMP2 chimera 分子名称: AB204 Activin A/BMP2 chimera 著者 Esquivies, L. 登録日 2013-08-30 公開日 2014-05-07 最終更新日 2019-07-17 実験手法 X-RAY DIFFRACTION (2.139 Å) 主引用文献 An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2. J.Bone Miner.Res., 29, 2014
4MPL	Crystal structure of BMP9 at 1.90 Angstrom 分子名称: Growth/differentiation factor 2 著者 Li, W, Morrell, N.W, Wei, Z. 登録日 2013-09-13 公開日 2014-09-17 最終更新日 2021-06-02 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Regulation of Bone Morphogenetic Protein 9 (BMP9) by Redox-dependent Proteolysis. J.Biol.Chem., 289, 2014
4N1D	Nodal/BMP2 chimera NB250 分子名称: Nodal/BMP2 chimera protein 著者 Esquivies, L. 登録日 2013-10-04 公開日 2013-12-04 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (1.912 Å) 主引用文献 Designer Nodal/BMP2 Chimeras Mimic Nodal Signaling, Promote Chondrogenesis, and Reveal a BMP2-like Structure. J.Biol.Chem., 289, 2014
7ZJF	R399E, a mutated form of GDF5, for disease modification of osteoarthritis 分子名称: Growth/differentiation factor 5 著者 Gigout, A, Wekmann, D, Menges, S, Brenneis, C, Henson, F, Cowan, K.J, Musil, D, Thudium, C, Guehring, H, Michaelis, M, Kleinschmidt-Doerr, K. 登録日 2022-04-10 公開日 2022-09-28 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 R399E, A Mutated Form of Growth and Differentiation Factor 5, for Disease Modification of Osteoarthritis. Arthritis Rheumatol, 75, 2023
8E3G	BMP2/GDF5 heterodimer 分子名称: Bone morphogenetic protein 2, GLYCEROL, Growth/differentiation factor 5 著者 Gipson, G.R, Nolan, K.T, Thompson, T.B. 登録日 2022-08-17 公開日 2023-02-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers. Bmc Biol., 21, 2023
5VZ3	Growth Factor Crystal Structure at 1.97 Angstrom Resolution 分子名称: Growth/differentiation factor 15 著者 Lakshminarasimhan, D, White, A, Suto, R.K. 登録日 2017-05-26 公開日 2017-09-27 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15. Nature, 550, 2017
3BMP	HUMAN BONE MORPHOGENETIC PROTEIN-2 (BMP-2) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, PROTEIN (BONE MORPHOGENETIC PROTEIN 2 (BMP-2)) 著者 Scheufler, C, Sebald, W, Huelsmeyer, M. 登録日 1999-03-12 公開日 2000-03-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution. J.Mol.Biol., 287, 1999
5VT2	Crystal structure of growth differentiation factor 分子名称: 1,2-ETHANEDIOL, Growth/differentiation factor 15 著者 Min, X, Wang, Z. 登録日 2017-05-15 公開日 2017-11-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys. Sci Transl Med, 9, 2017
3BK3	Crystal structure of the complex of BMP-2 and the first Von Willebrand domain type C of Crossveinless-2 分子名称: Bone morphogenetic protein 2, Crossveinless 2 著者 Mueller, T.D, Sebald, W, Zhang, J.-L. 登録日 2007-12-05 公開日 2008-05-27 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding Dev.Cell, 14, 2008
2ARV	Structure of human Activin A 分子名称: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, GLYCEROL, Inhibin beta A chain, ... 著者 Harrington, A.E, Morris-Triggs, S.A, Ruotolo, B.T, Robinson, C.V, Ohnuma, S, Hyvonen, M. 登録日 2005-08-22 公開日 2006-03-07 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for the inhibition of activin signalling by follistatin Embo J., 25, 2006
2ASK	Structure of human Artemin 分子名称: SULFATE ION, artemin 著者 Silvian, L, Jin, P, Carmillo, P, Boriack-Sjodin, P.A, Pelletier, C, Rushe, M, Gong, B.J, Sah, D, Pepinsky, B, Rossomando, A. 登録日 2005-08-23 公開日 2006-06-13 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Artemin crystal structure reveals insights into heparan sulfate binding. Biochemistry, 45, 2006
6SF3	Bone morphogenetic protein 10 (BMP10) in complex with extracellular domain of activin receptor-like kinase 1 (ALK1) at 2.3 Angstrom 分子名称: Bone morphogenetic protein 10, Serine/threonine-protein kinase receptor R3 著者 Guo, J, Yu, M, Li, W. 登録日 2019-07-31 公開日 2020-04-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.30000663 Å) 主引用文献 Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms. Nat Commun, 11, 2020
6SF1	Bone morphogenetic protein 10 (BMP10) complexed with extracellular domain of activin receptor-like kinase 1 (ALK1). 分子名称: Bone morphogenetic protein 10, NICKEL (II) ION, Serine/threonine-protein kinase receptor R3 著者 Salmon, R.M, Guo, J, Yu, M, Li, W. 登録日 2019-07-30 公開日 2020-04-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms. Nat Commun, 11, 2020
2BHK	Crystal structure of human growth and differentiation factor 5 (GDF5) 分子名称: GROWTH DIFFERENTIATION FACTOR 5, ISOPROPYL ALCOHOL 著者 Schreuder, H, Liesum, A, Pohl, J, Kruse, M, Koyama, M. 登録日 2005-01-12 公開日 2005-03-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of Recombinant Human Growth Differentiation Factor 5. Evidence for Interaction of the Type I and Type II Receptor Binding Sites. Biochem.Biophys.Res.Commun., 329, 2005
5TX6	Structure of TGF-beta2 derivative with deletion of residues 52-71 and 10 single amino acid mutations (mmTGF-beta2-7M) 分子名称: CALCIUM ION, Transforming growth factor beta-2 著者 Petrunak, E.M, Hinck, A.P. 登録日 2016-11-15 公開日 2017-03-01 最終更新日 2019-12-04 実験手法 X-RAY DIFFRACTION (2.746 Å) 主引用文献 An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling. J. Biol. Chem., 292, 2017

 

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