PDB: 9760 件ウェブページステータス検索Chemie searchBIRD

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7SD5	Crystallographic structure of neutralizing antibody 10-40 in complex with SARS-CoV-2 spike receptor binding domain 分子名称: 10-40 Heavy chain, 10-40 Light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Reddem, E.R, Casner, R.G, Shapiro, L. 登録日 2021-09-29 公開日 2022-04-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses. Sci Transl Med, 14, 2022
7SI2	Crystal structure of neutralizing antibody 10-28 in complex with SARS-CoV-2 spike receptor binding domain (RBD) 分子名称: 10-28 Heavy Chain, 10-28 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Reddem, E.R, Shapiro, L. 登録日 2021-10-12 公開日 2022-04-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses. Sci Transl Med, 14, 2022
6B5T	Structure of PfCSP peptide 29 with human antibody CIS42 分子名称: AMMONIUM ION, CIS42 Fab Heavy chain, CIS42 Fab Light chain, ... 著者 Pancera, M, Weidle, C. 登録日 2017-09-29 公開日 2018-03-21 最終更新日 2018-04-25 実験手法 X-RAY DIFFRACTION (2.222 Å) 主引用文献 A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. Nat. Med., 24, 2018
6BP2	Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, Envelope glycoprotein GP2, ... 著者 King, L.B, Fusco, M.L, Flyak, A.I, Ilinykh, P.A, Huang, K, Gunn, B, Kirchdoerfer, R.N, Hastie, K.M, Sangha, A.K, Meiler, J, Alter, G, Bukreyev, A, Crowe, J.E.J, Saphire, E.O. 登録日 2017-11-21 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.172 Å) 主引用文献 The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding. Cell Host Microbe, 23, 2018
6B5O	Structure of PfCSP peptide 29 with human protective antibody CIS43 分子名称: CIS43 Fab Heavy chain, CIS43 Fab Light chain, PfCSP peptide 29: ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN 著者 Pancera, M, Weidle, C. 登録日 2017-09-29 公開日 2018-03-21 最終更新日 2018-04-25 実験手法 X-RAY DIFFRACTION (2.194 Å) 主引用文献 A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. Nat. Med., 24, 2018
8TNL	CryoEM structure of H7 hemagglutinin from A/Shanghai2/2013 H7N9 in complex with a human neutralizing antibody H7.HK1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, H7.HK1 Neutralizing Antibody Heavy Chain, Hemagglutinin 著者 Morano, N.C, Wu, X, Shapiro, L. 登録日 2023-08-02 公開日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.62 Å) 主引用文献 CryoEM structure of H7 hemagglutinin from A/Shanghai2/2013 H7N9 in complex with a human neutralizing antibody H7.HK1 To Be Published
1CT8	CATALYTIC ANTIBODY 7C8 COMPLEX 分子名称: 7C8 FAB FRAGMENT; LONG CHAIN, 7C8 FAB FRAGMENT; SHORT CHAIN, SULFATE ION, ... 著者 Gigant, B, Tsumuraya, T, Fujii, I, Knossow, M. 登録日 1999-08-20 公開日 1999-11-10 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Diverse structural solutions to catalysis in a family of antibodies. Structure Fold.Des., 7, 1999
7KI6	Structure of the HeV F glycoprotein in complex with the 1F5 neutralizing antibody 分子名称: 1F5 Fab light chain, 1F5 heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Dang, H.V, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 登録日 2020-10-23 公開日 2021-05-05 最終更新日 2021-06-23 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins. Nat.Struct.Mol.Biol., 28, 2021
7KI4	Structure of the NiV F glycoprotein in complex with the 12B2 neutralizing antibody 分子名称: 12B2 Fab light chain, 12B2 heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Dang, H.V, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 登録日 2020-10-23 公開日 2021-05-05 最終更新日 2021-05-26 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins. Nat.Struct.Mol.Biol., 28, 2021
6WN1	Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 241242 分子名称: 241242 Fab heavy chain, 241242 Fab light chain, Reticulocyte binding protein 2b 著者 Chan, L.J, Dietrich, M.H, Tham, W.H. 登録日 2020-04-22 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b. Nat Commun, 12, 2021
8C2R	SARS-CoV2 Omicron BA.1 spike in complex with CAB-A17 antibody 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CAB-A17 antibody (HC), ... 著者 Das, H, Hallberg, B.M. 登録日 2022-12-22 公開日 2024-05-22 実験手法 ELECTRON MICROSCOPY (2.56 Å) 主引用文献 SARS-CoV-2 omicron Spike (RBD) in complex with CAB-A17 antibody To Be Published
6WNO	Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 243244 分子名称: 243244 Fab heavy chain, 243244 Fab light chain, Plasmodium vivax reticulocyte binding protein 2b 著者 Chan, L.J, Dietrich, M.H, Tham, W.H. 登録日 2020-04-23 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b. Nat Commun, 12, 2021
6WOZ	Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 251249 分子名称: 251249 Fab heavy chain, 251249 Fab light chain, reticulocyte binding protein 2b 著者 Chan, L.J, Dietrich, M.H, Tham, W.H. 登録日 2020-04-26 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b. Nat Commun, 12, 2021
7SQ1	BG505.MD39TS Env trimer in complex with Fab from antibody C05 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C05 Fab Light chain, ... 著者 Moore, A, Du, J, Xu, Z, Walker, S, Kulp, D.W, Pallesen, J. 登録日 2021-11-04 公開日 2022-06-22 最終更新日 2022-12-07 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer. Nat Commun, 13, 2022
8DY6	Vaccine elicited Antibody MU89+S27Y bound to CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 Env trimer 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Stalls, V, Acharya, P. 登録日 2022-08-03 公開日 2023-04-19 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.32 Å) 主引用文献 Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction. Cell Host Microbe, 32, 2024
6MZJ	Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer, 2 Fabs bound, sharpened map 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 426c DS-SOSIP D3, ... 著者 Borst, A.J, Weidle, C.E, Gray, M.D, Frenz, B, Snijder, J, Joyce, M.G, Georgiev, I.S, Stewart-Jones, G.B.E, Kwong, P.D, McGuire, A.T, DiMaio, F, Stamatatos, L, Pancera, M, Veesler, D. 登録日 2018-11-05 公開日 2018-11-14 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.8 Å) 主引用文献 Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core. Elife, 7, 2018
5MO9	Structure of human TrkB receptor ligand binding domain in complex with the Fab frgment of antibody AB20 分子名称: AB20 Fab heavy chain, AB20 Fab light chain, BDNF/NT-3 growth factors receptor 著者 Hoerer, S. 登録日 2016-12-14 公開日 2017-08-02 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.594 Å) 主引用文献 Pharmaceutical Characterization of Tropomyosin Receptor Kinase B-Agonistic Antibodies on Human Induced Pluripotent Stem (hiPS) Cell-Derived Neurons. J. Pharmacol. Exp. Ther., 361, 2017
7E9B	Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy 分子名称: Programmed cell death protein 1, heavy chain of Fab fragment of HLX10, light chain of Fab fragment of HLX10 著者 Fan, S.L, Jiang, W.D. 登録日 2021-03-04 公開日 2021-07-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy. Plos One, 16, 2021
6WM9	Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 237235 分子名称: 237235 Fab heavy chain, 237235 Fab light chain, Reticulocyte binding protein 2b 著者 Chan, L.J, Dietrich, M.H, Tham, W.H. 登録日 2020-04-20 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b. Nat Commun, 12, 2021
4LLD	Structure of wild-type IgG1 antibody heavy chain constant domain 1 and light chain lambda constant domain (IgG1 CH1:Clambda) at 1.19A 分子名称: Ig gamma-1 chain C region, Ig lambda-2 chain C region 著者 Pustilnik, A, Lewis, S.M, Wu, X, Sereno, A, Huang, F, Guntas, G, Leaver-Fay, A, Smith, E.M, Ho, C, Hansen-Estruch, C, Chamberlain, A.K, Truhlar, S.M, Kuhlman, B, Demarest, S.J, Atwell, S. 登録日 2013-07-09 公開日 2014-01-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.19 Å) 主引用文献 Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Nat.Biotechnol., 32, 2014
7E3K	Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants 分子名称: 13G9 heavy chain, 13G9 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Guo, H, Li, T, Liu, F, Gao, Y, Ji, X, Yang, H. 登録日 2021-02-09 公開日 2021-09-15 最終更新日 2022-03-02 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants. Nat Commun, 12, 2021
5CD3	Structure of immature VRC01-class antibody DRVIA7 分子名称: DRVIA7 Heavy Chain, DRVIA7 Light Chain 著者 Kong, L, Wilson, I.A. 登録日 2015-07-02 公開日 2016-04-06 最終更新日 2018-09-05 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor. Immunity, 44, 2016
4Q6I	Crystal structure of murine 2D5 Fab, a potent anti-CD4 HIV-1-neutralizing antibody in complex with CD4 分子名称: Heavy chain of murine 2D5 Fab, Light chain of murine 2D5 Fab, T-cell surface glycoprotein CD4 著者 Boyington, J.C, Nabel, G.J, Mascola, J.R. 登録日 2014-04-22 公開日 2014-07-23 実験手法 X-RAY DIFFRACTION (3.65 Å) 主引用文献 Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor. Sci Transl Med, 6, 2014
5CGY	Fab fragment of Chikungunya virus neutralizing human monoclonal antibody 4J21 分子名称: Heavy Chain of Fab, Light Chain of Fab 著者 Long, F, Crowe, J.E, Rossmann, M.G. 登録日 2015-07-09 公開日 2015-11-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity. Proc.Natl.Acad.Sci.USA, 112, 2015
4P2C	Complex of Shiga toxin 2e with a neutralizing single-domain antibody 分子名称: Nanobody 1, Anti-F4+ETEC bacteria VHH variable region, Shiga toxin 2e, ... 著者 Lo, A.W.H, Moonens, K, De Kerpel, M, Brys, L, Pardon, E, Remaut, H, De Greve, H. 登録日 2014-03-03 公開日 2014-07-30 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.818 Å) 主引用文献 The Molecular Mechanism of Shiga Toxin Stx2e Neutralization by a Single-domain Antibody Targeting the Cell Receptor-binding Domain. J.Biol.Chem., 289, 2014

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