1CT8

CATALYTIC ANTIBODY 7C8 COMPLEX

Summary for 1CT8

• Entry DOI: 10.2210/pdb1ct8/pdb
• Descriptor: 7C8 FAB FRAGMENT; SHORT CHAIN, 7C8 FAB FRAGMENT; LONG CHAIN, SULFATE ION, ... (5 entities in total)
• Functional Keywords: abzyme transition state analog, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 4
• Total formula weight: 95801.88

Authors

Gigant, B.,Tsumuraya, T.,Fujii, I.,Knossow, M. (deposition date: 1999-08-20, release date: 1999-11-10, Last modification date: 2011-07-13)

Primary citation

Gigant, B.,Tsumuraya, T.,Fujii, I.,Knossow, M.
Diverse structural solutions to catalysis in a family of antibodies.
Structure Fold.Des., 7:1385-1393, 1999

PubMed Abstract: Small organic molecules coupled to a carrier protein elicit an antibody response on immunisation. The diversity of this response has been found to be very narrow in several cases. Some antibodies also catalyse chemical reactions. Such catalytic antibodies are usually identified among those that bind tightly to an analogue of the transition state (TSA) of the relevant reaction; therefore, catalytic antibodies are also thought to have restricted diversity. To further characterise this diversity, we investigated the structure and biochemistry of the catalytic antibody 7C8, one of the most efficient of those which enhance the hydrolysis of chloramphenicol esters, and compared it to the other catalytic antibodies elicited in the same immunisation.

PubMed: 10574796
DOI: 10.1016/S0969-2126(00)80028-3

Experimental method

X-RAY DIFFRACTION (2.2 Å)