Structure of PfCSP peptide 29 with human antibody CIS42

Summary for 6B5T

Related6B5P 6B5R 6B5S
DescriptorpfCSP peptide 29: ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA, CIS42 Fab Heavy chain, CIS42 Fab Light chain, ... (5 entities in total)
Functional Keywordsmalaria, pfcsp, vaccine, antibodies, immune system
Biological sourceHomo sapiens
Total number of polymer chains3
Total molecular weight47897.17
Pancera, M.,Weidle, C. (deposition date: 2017-09-29, release date: 2018-03-21, Last modification date: 2018-04-25)
Primary citation
Kisalu, N.K.,Idris, A.H.,Weidle, C.,Flores-Garcia, Y.,Flynn, B.J.,Sack, B.K.,Murphy, S.,Schon, A.,Freire, E.,Francica, J.R.,Miller, A.B.,Gregory, J.,March, S.,Liao, H.X.,Haynes, B.F.,Wiehe, K.,Trama, A.M.,Saunders, K.O.,Gladden, M.A.,Monroe, A.,Bonsignori, M.,Kanekiyo, M.,Wheatley, A.K.,McDermott, A.B.,Farney, S.K.,Chuang, G.Y.,Zhang, B.,Kc, N.,Chakravarty, S.,Kwong, P.D.,Sinnis, P.,Bhatia, S.N.,Kappe, S.H.I.,Sim, B.K.L.,Hoffman, S.L.,Zavala, F.,Pancera, M.,Seder, R.A.
A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.
Nat. Med., 24:408-416, 2018
PubMed: 29554083 (PDB entries with the same primary citation)
DOI: 10.1038/nm.4512
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.210200.5%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution