7E9B

Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy

Summary for 7E9B

• Entry DOI: 10.2210/pdb7e9b/pdb
• Descriptor: heavy chain of Fab fragment of HLX10, light chain of Fab fragment of HLX10, Programmed cell death protein 1, ... (4 entities in total)
• Functional Keywords: antibody, mab, pd-1, pd-l-1, cancer, t-cell, immunotherapy, ici, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 59205.97

Authors

Fan, S.L.,Jiang, W.D. (deposition date: 2021-03-04, release date: 2021-07-28, Last modification date: 2023-11-29)

• Primary citation: Issafras, H.,Fan, S.,Tseng, C.L.,Cheng, Y.,Lin, P.,Xiao, L.,Huang, Y.J.,Tu, C.H.,Hsiao, Y.C.,Li, M.,Chen, Y.H.,Ho, C.H.,Li, O.,Wang, Y.,Chen, S.,Ji, Z.,Zhang, E.,Mao, Y.T.,Liu, E.,Yang, S.,Jiang, W.; Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy.; Plos One, 16:e0257972-e0257972, 2021; PubMed: 34972111; DOI: 10.1371/journal.pone.0257972

Experimental method

X-RAY DIFFRACTION (1.78 Å)