7E9B
Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR192-HIS198 | |
| H | TYR197-HIS203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 110 |
| Details | Domain: {"description":"Ig-like V-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Region: {"description":"Interaction with CD274/PDCD1L1","evidences":[{"source":"PubMed","id":"26602187","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 25 |
| Details | Region: {"description":"Pembrolizumab binding","evidences":[{"source":"PubMed","id":"27325296","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27734966","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5B8C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JXE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28165004","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28165004","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WT9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
