4Q6I

Crystal structure of murine 2D5 Fab, a potent anti-CD4 HIV-1-neutralizing antibody in complex with CD4

Summary for 4Q6I

• Entry DOI: 10.2210/pdb4q6i/pdb
• Descriptor: Light chain of murine 2D5 Fab, Heavy chain of murine 2D5 Fab, T-cell surface glycoprotein CD4 (3 entities in total)
• Functional Keywords: ig fold, antibody, anti-cd4, hiv-1 neutralization, cd4, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P01730
• Total number of polymer chains: 12
• Total formula weight: 287960.09

Authors

Boyington, J.C.,Nabel, G.J.,Mascola, J.R. (deposition date: 2014-04-22, release date: 2014-07-23)

• Primary citation: Pegu, A.,Yang, Z.Y.,Boyington, J.C.,Wu, L.,Ko, S.Y.,Schmidt, S.D.,McKee, K.,Kong, W.P.,Shi, W.,Chen, X.,Todd, J.P.,Letvin, N.L.,Huang, J.,Nason, M.C.,Hoxie, J.A.,Kwong, P.D.,Connors, M.,Rao, S.S.,Mascola, J.R.,Nabel, G.J.; Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor.; Sci Transl Med, 6:243ra88-243ra88, 2014; PubMed: 24990883; DOI: 10.1126/scitranslmed.3008992

Experimental method

X-RAY DIFFRACTION (3.65 Å)