5MO9

Structure of human TrkB receptor ligand binding domain in complex with the Fab frgment of antibody AB20

Summary for 5MO9

• Entry DOI: 10.2210/pdb5mo9/pdb
• Descriptor: AB20 Fab heavy chain, AB20 Fab light chain, BDNF/NT-3 growth factors receptor, ... (4 entities in total)
• Functional Keywords: trk receptor, antibody, antigen, complex, immune system
• Biological source: Mus musculus (House mouse); More
• Total number of polymer chains: 3
• Total formula weight: 64516.75

Authors

Hoerer, S. (deposition date: 2016-12-14, release date: 2017-08-02, Last modification date: 2024-01-17)

• Primary citation: Traub, S.,Stahl, H.,Rosenbrock, H.,Simon, E.,Florin, L.,Hospach, L.,Horer, S.,Heilker, R.; Pharmaceutical Characterization of Tropomyosin Receptor Kinase B-Agonistic Antibodies on Human Induced Pluripotent Stem (hiPS) Cell-Derived Neurons.; J. Pharmacol. Exp. Ther., 361:355-365, 2017; PubMed: 28351853; DOI: 10.1124/jpet.117.240184

Experimental method

X-RAY DIFFRACTION (2.594 Å)