PDB: 292 件ウェブページステータス検索Chemie searchBIRD

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4U54	IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR 分子名称: Importin subunit alpha-1, N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine 著者 Stewart, M, Valkov, E, Holvey, R.S. 登録日 2014-07-24 公開日 2015-05-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10, 2015
4UAD	Importin alpha 7 delta IBB in complex with Influenza PB2 Nuclear Localization Domain 分子名称: Importin subunit alpha-7, Polymerase basic protein 2 著者 Pumroy, R.A, Cingolani, G. 登録日 2014-08-08 公開日 2015-02-04 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Molecular Determinants for Nuclear Import of Influenza A PB2 by Importin alpha Isoforms 3 and 7. Structure, 23, 2015
7VPT	Structure of the C. glabrata importin alpha ARM domain - Upc2 NLS fusion 分子名称: C. glabrata importin alpha ARM domain - Upc2 NLS fusion 著者 Tan, L, Im, Y.J. 登録日 2021-10-18 公開日 2022-09-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for activation of fungal sterol receptor Upc2 and azole resistance. Nat.Chem.Biol., 18, 2022
1QGK	STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA 分子名称: PROTEIN (IMPORTIN ALPHA-2 SUBUNIT), PROTEIN (IMPORTIN BETA SUBUNIT) 著者 Cingolani, G, Petosa, C, Weis, K, Muller, C.W. 登録日 1999-04-29 公開日 1999-05-24 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of importin-beta bound to the IBB domain of importin-alpha. Nature, 399, 1999
3SLA	X-ray structure of first four repeats of human beta-catenin 分子名称: Catenin beta-1, GLYCEROL, SODIUM ION 著者 Gupta, D, Bienz, M. 登録日 2011-06-24 公開日 2012-02-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 An intrinsically labile alpha-helix abutting the BCL9-binding site of beta-catenin is required for its inhibition by carnosic acid. Nat Commun, 3, 2012
5H2W	Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-340) 分子名称: Importin subunit alpha, Ubiquitin-like-specific protease 1 著者 Hirano, H, Matsuura, Y. 登録日 2016-10-18 公開日 2016-12-14 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p J. Mol. Biol., 429, 2017
1TH1	Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment 分子名称: Adenomatous polyposis coli protein, Beta-catenin 著者 Xing, Y, Clements, W.K, Le Trong, I, Hinds, T.R, Stenkamp, R, Kimelman, D, Xu, W. 登録日 2004-05-31 公開日 2004-09-07 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of a beta-Catenin/APC Complex Reveals a Critical Role for APC Phosphorylation in APC Function. Mol.Cell, 15, 2004
1JPW	Crystal Structure of a Human Tcf-4 / beta-Catenin Complex 分子名称: BETA-CATENIN, transcription factor 7-like 2 著者 Poy, F, Lepourcelet, M, Shivdasani, R.A, Eck, M.J. 登録日 2001-08-03 公開日 2001-12-05 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of a human Tcf4-beta-catenin complex. Nat.Struct.Biol., 8, 2001
7RFY	Importin alpha3 in complex with MERS ORF4B 分子名称: Importin subunit alpha-3, ORF4b 著者 Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. 登録日 2021-07-14 公開日 2021-07-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
1IAL	IMPORTIN ALPHA, MOUSE 分子名称: IMPORTIN ALPHA 著者 Kobe, B. 登録日 1999-01-12 公開日 1999-06-15 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha. Nat.Struct.Biol., 6, 1999
3Q5U	A minimal NLS from human scramblase 4 complexed with importin alpha 分子名称: Importin subunit alpha-2, Phospholipid scramblase 4 著者 Bhardwaj, A, Cingolani, G. 登録日 2010-12-29 公開日 2011-06-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A Minimal Nuclear Localization Signal (NLS) in Human Phospholipid Scramblase 4 That Binds Only the Minor NLS-binding Site of Importin {alpha}1. J.Biol.Chem., 286, 2011
7RHT	Importin alpha 7 delta IBB (KPNA6) 分子名称: Importin subunit alpha-7 著者 Tsimbalyuk, S, Forwood, J.K. 登録日 2021-07-18 公開日 2022-02-23 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural characterization of human importin alpha 7 in its cargo-free form at 2.5 angstrom resolution. Sci Rep, 12, 2022
8Y0G	Human beta-catenin crystal structure 分子名称: Catenin beta-1 著者 Tim, F. 登録日 2024-01-22 公開日 2024-03-13 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal protein of human Beta-catenin To Be Published
8Z61	Human beta-catenin crystal structure 分子名称: Catenin beta-1 著者 Tim, F. 登録日 2024-04-18 公開日 2024-05-08 最終更新日 2024-07-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of Novel 1-Phenylpiperidine Urea-Containing Derivatives Inhibiting beta-Catenin/BCL9 Interaction and Exerting Antitumor Efficacy through the Activation of Antigen Presentation of cDC1 Cells. J.Med.Chem., 2024
8TUU	MW Polyomavirus LTA bipartite NLS bound to importin alpha 2 分子名称: Importin subunit alpha-1, Large T-antigen 著者 Cross, E.M, Forwood, J.K, Alvisi, G. 登録日 2023-08-17 公開日 2024-02-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
1LUJ	Crystal Structure of the Beta-catenin/ICAT Complex 分子名称: Beta-catenin-interacting protein 1, Catenin beta-1 著者 Graham, T.A, Clements, W.K, Kimelman, D, Xu, W. 登録日 2002-05-22 公開日 2002-10-16 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT. Mol.Cell, 10, 2002
4PVZ	Structure of yeast importin a bound to the membrane protein Nuclear Localization Signal sequence of INM protein Heh2 分子名称: Importin subunit alpha, Inner nuclear membrane protein HEH2 著者 Lokareddy, R.K, Hapsari, A.R, van Rheenen, M, Bhardwaj, A, Veenhoff, L.M, Cingolani, C. 登録日 2014-03-18 公開日 2015-08-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2. Structure, 23, 2015
1PJN	Mouse Importin alpha-bipartite NLS N1N2 from Xenopus laevis phosphoprotein Complex 分子名称: Histone-binding protein N1/N2, Importin alpha-2 subunit 著者 Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B. 登録日 2003-06-03 公開日 2003-08-19 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha J.Biol.Chem., 278, 2003
1PJM	Mouse Importin alpha-bipartite NLS from human retinoblastoma protein Complex 分子名称: Importin alpha-2 subunit, Retinoblastoma-associated protein 著者 Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B. 登録日 2003-06-03 公開日 2003-08-19 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha J.Biol.Chem., 278, 2003
6MJL	Crystal structure of ChREBP NLS peptide bound to importin alpha. 分子名称: ChREBP Peptide ASN-TYR-TRP-LYS-ARG-ARG-ILE-GLU-VAL, Importin subunit alpha-1 著者 Jung, H, Uyeda, K. 登録日 2018-09-21 公開日 2019-09-25 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The structure of importin alpha and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP-importin alpha interactions. Biochem.J., 477, 2020
6BVT	Importin alpha 1 in cargo free state 分子名称: Importin subunit alpha-1 著者 Smith, K.M, Tsimablyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. 登録日 2017-12-13 公開日 2018-07-04 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
1Q1T	Mouse Importin alpha: non-phosphorylated SV40 CN peptide complex 分子名称: Importin alpha-2 subunit, Large T antigen 著者 Fontes, M.R.M, Teh, T, Toth, G, John, A, Pavo, I, Jans, D.A, Kobe, B. 登録日 2003-07-22 公開日 2004-03-30 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha Biochem.J., 375, 2003
5VQI	Nuclear transport of the Neurospora crassa NIT2 transcription factor is mediated by Importin-alpha 分子名称: Importin subunit alpha, Nuclear localization sequence of NIT2 transcription factor (NIT2-NLS) 著者 Bernardes, N.E, Fontes, M.R.M. 登録日 2017-05-09 公開日 2017-11-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.501 Å) 主引用文献 Nuclear transport of the Neurospora crassa NIT-2 transcription factor is mediated by importin-alpha. Biochem. J., 474, 2017
4B18	The crystal structure of human Importin alpha 5 with TERT NLS peptide 分子名称: IMPORTIN SUBUNIT ALPHA-1, TELOMERASE REVERSE TRANSCRIPTASE 著者 Kim, K.L, Yoo, J.H, Cho, H.S. 登録日 2012-07-08 公開日 2013-09-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Akt-Mediated Phosphorylation Increases the Binding Affinity of Htert for Importin Alpha to Promote Nuclear Translocation. J.Cell.Sci., 128, 2015
4E4V	The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution. 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, Importin subunit alpha-2 著者 Hang, P.C, Miknis, Z.M, Franke, W.A, Umland, T.C, Schultz, L.W. 登録日 2012-03-13 公開日 2013-05-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5283 Å) 主引用文献 The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution. To be Published

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