8Z61

Human beta-catenin crystal structure

Summary for 8Z61

Entry DOI	10.2210/pdb8z61/pdb
Descriptor	Catenin beta-1 (1 entity in total)
Functional Keywords	bcl9, beta-catenin, structural protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	60187.65
Authors	Tim, F. (deposition date: 2024-04-18, release date: 2024-05-08, Last modification date: 2024-07-24)
Primary citation	Zhu, W.,Liu, C.,Xi, K.,Li, A.,Shen, L.A.,Li, Y.,Jia, M.,He, Y.,Chen, G.,Liu, C.,Chen, Y.,Chen, K.,Sun, F.,Zhang, D.,Duan, C.,Wang, H.,Wang, D.,Zhao, Y.,Meng, X.,Zhu, D. Discovery of Novel 1-Phenylpiperidine Urea-Containing Derivatives Inhibiting beta-Catenin/BCL9 Interaction and Exerting Antitumor Efficacy through the Activation of Antigen Presentation of cDC1 Cells. J.Med.Chem., 2024 Cited by PubMed: 38912577 DOI: 10.1021/acs.jmedchem.3c02079 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation