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4U54

IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR

Summary for 4U54
Entry DOI10.2210/pdb4u54/pdb
DescriptorImportin subunit alpha-1, N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine (3 entities in total)
Functional Keywordstpx2 inhibitor, transport protein
Biological sourceMus musculus (Mouse)
Cellular locationCytoplasm : P52293
Total number of polymer chains1
Total formula weight46283.07
Authors
Stewart, M.,Valkov, E.,Holvey, R.S. (deposition date: 2014-07-24, release date: 2015-05-13, Last modification date: 2015-07-08)
Primary citationHolvey, R.S.,Valkov, E.,Neal, D.,Stewart, M.,Abell, C.
Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10:1232-1239, 2015
Cited by
PubMed: 25899172
DOI: 10.1002/cmdc.201500014
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.41 Å)
Structure validation

217705

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