PDB: 872 件ウェブページステータス検索Chemie searchBIRD

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7YON	Complex structure of Neuropeptide Y Y2 receptor in complex with PYY(3-36) and Gi 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Kang, H, Park, C, Kim, J, Choi, H.-J. 登録日 2022-08-01 公開日 2023-03-22 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling. Structure, 31, 2023
1TL7	Complex Of Gs- With The Catalytic Domains Of Mammalian Adenylyl Cyclase: Complex With 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-triphosphate and Mn 分子名称: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase, ... 著者 Mou, T.C, Gille, A, Seifert, R.J, Sprang, S.R. 登録日 2004-06-09 公開日 2004-12-14 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate. J.Biol.Chem., 280, 2005
1GG2	G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND 分子名称: G PROTEIN GI ALPHA 1, G PROTEIN GI BETA 1, G PROTEIN GI GAMMA 2, ... 著者 Wall, M.A, Sprang, S.R. 登録日 1996-11-13 公開日 1997-02-12 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell(Cambridge,Mass.), 83, 1995
1GOT	HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS 分子名称: GT-ALPHA/GI-ALPHA CHIMERA, GT-BETA, GT-GAMMA, ... 著者 Lambright, D.G, Sondek, J, Bohm, A, Skiba, N.P, Hamm, H.E, Sigler, P.B. 登録日 1996-08-07 公開日 1997-03-12 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The 2.0 A crystal structure of a heterotrimeric G protein. Nature, 379, 1996
1GP2	G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND 分子名称: G PROTEIN GI ALPHA 1, G PROTEIN GI BETA 1, G PROTEIN GI GAMMA 2, ... 著者 Wall, M.A, Sprang, S.R. 登録日 1996-11-13 公開日 1997-02-12 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell(Cambridge,Mass.), 83, 1995
7LJD	Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex with miniGs protein 分子名称: 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, D(1A) dopamine receptor, ... 著者 Zhuang, Y, Krumm, B, Zhang, H, Zhou, X.E, Wang, Y, Guo, J, Huang, X.-P, Liu, Y, Wang, L, Cheng, X, Jiang, Y, Jiang, H, Melcher, K, Zhang, C, Yi, W, Roth, B.L, Zhang, Y, Xu, H.E. 登録日 2021-01-28 公開日 2021-03-03 最終更新日 2021-05-12 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor. Cell Res., 31, 2021
7LLY	Oxyntomodulin-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein 分子名称: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wootten, D, Sexton, P.M, Belousoff, M.J, Danev, R, Zhang, X, Khoshouei, M, Venugopal, H. 登録日 2021-02-04 公開日 2022-01-12 最終更新日 2022-01-26 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun, 13, 2022
7LLL	Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein 分子名称: Exendin-4, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Wootten, D, Sexton, P.M, Belousoff, M.J, Danev, R, Zhang, X, Khoshouei, M, Venugopal, H. 登録日 2021-02-04 公開日 2022-01-12 最終更新日 2022-01-26 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun, 13, 2022
7MTS	CryoEM Structure of mGlu2 - Gi Complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine, GLUTAMIC ACID, ... 著者 Seven, A.B, Barros-Alvarez, X, Skiniotis, G. 登録日 2021-05-13 公開日 2021-07-07 最終更新日 2021-07-28 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 G-protein activation by a metabotropic glutamate receptor. Nature, 595, 2021
7MBY	Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex 分子名称: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ... 著者 Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M. 登録日 2021-04-01 公開日 2021-05-26 最終更新日 2021-07-14 実験手法 ELECTRON MICROSCOPY (2.44 Å) 主引用文献 Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. Plos Biol., 19, 2021
7MBX	Human Cholecystokinin 1 receptor (CCK1R) Gs complex 分子名称: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ... 著者 Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M. 登録日 2021-04-01 公開日 2021-05-26 最終更新日 2021-07-14 実験手法 ELECTRON MICROSCOPY (1.95 Å) 主引用文献 Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. Plos Biol., 19, 2021
7NA7	Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist 分子名称: Antibody fragment, CHOLESTEROL, Ghrelin-27, ... 著者 Liu, H, Sun, D, Sun, J, Zhang, C. 登録日 2021-06-20 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren Nat Commun, 12, 2021
7NA8	Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist 分子名称: 1-(methanesulfonyl)-1'-(2-methyl-L-alanyl-O-benzyl-D-seryl)-1,2-dihydrospiro[indole-3,4'-piperidine], Antibody fragment, CHOLESTEROL, ... 著者 Liu, H, Sun, D, Sun, J, Zhang, C. 登録日 2021-06-20 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren Nat Commun, 12, 2021
7LD3	Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist and an allosteric ligand 分子名称: ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Draper-Joyce, C.J, Danev, R, Thal, D.M, Christopoulos, A, Glukhova, A. 登録日 2021-01-12 公開日 2021-09-08 最終更新日 2021-10-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia. Nature, 597, 2021
7LD4	Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist 分子名称: ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Draper-Joyce, C.J, Danev, R, Thal, D.M, Christopoulos, A, Glukhova, A. 登録日 2021-01-12 公開日 2021-09-08 最終更新日 2021-10-13 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia. Nature, 597, 2021
7O7F	Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist 分子名称: C-C chemokine receptor type 5, C-C motif chemokine 5, Fab antibody fragment heavy chain, ... 著者 Isaikina, P, Tsai, C.-J, Dietz, N.B, Pamula, F, Goldie, K.N, Schertler, G.F.X, Maier, T, Stahlberg, H, Deupi, X, Grzesiek, S. 登録日 2021-04-13 公開日 2021-06-30 最終更新日 2022-03-16 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist. Sci Adv, 7, 2021
6PB0	Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 1 receptor in complex with Gs protein and Nb35 分子名称: CHOLESTEROL, Corticotropin-releasing factor receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Ma, S, Shen, Q, Zhao, L.-H, Mao, C, Zhou, X.E, Shen, D.-D, de Waal, P.W, Bi, P, Li, C, Jiang, Y, Wang, M.-W, Sexton, P.M, Wootten, D, Melcher, K, Zhang, Y, Xu, H.E. 登録日 2019-06-12 公開日 2020-02-12 最終更新日 2020-02-19 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors. Mol.Cell, 77, 2020
6P9X	CRF1 Receptor Gs GPCR protein complex with CRF1 peptide 分子名称: Corticoliberin, Corticotropin-releasing factor receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. 登録日 2019-06-10 公開日 2020-02-05 最終更新日 2020-02-19 実験手法 ELECTRON MICROSCOPY (2.91 Å) 主引用文献 Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation. Mol.Cell, 77, 2020
6P9Y	PAC1 GPCR Receptor complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. 登録日 2019-06-10 公開日 2020-02-05 最終更新日 2020-02-19 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation. Mol.Cell, 77, 2020
6PB1	Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 2 receptor in complex with Gs protein and Nb35 分子名称: CHOLESTEROL, Corticotropin-releasing factor receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Ma, S, Shen, Q, Zhao, L.-H, Mao, C, Zhou, X.E, Shen, D.-D, de Waal, P.W, Bi, P, Li, C, Jiang, Y, Wang, M.-W, Sexton, P.M, Wootten, D, Melcher, K, Zhang, Y, Xu, H.E. 登録日 2019-06-12 公開日 2020-02-12 最終更新日 2020-02-19 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors. Mol.Cell, 77, 2020
6PT0	Cryo-EM structure of human cannabinoid receptor 2-Gi protein in complex with agonist WIN 55,212-2 分子名称: CHOLESTEROL, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Xu, T.H, Xing, C, Zhuang, Y, Feng, Z, Zhou, X.E, Chen, M, Wang, L, Meng, X, Xue, Y, Wang, J, Liu, H, McGuire, T, Zhao, G, Melcher, K, Zhang, C, Xu, H.E, Xie, X.Q. 登録日 2019-07-14 公開日 2020-02-12 最終更新日 2020-03-04 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-EM Structure of the Human Cannabinoid Receptor CB2-GiSignaling Complex. Cell, 180, 2020
6OIK	Muscarinic acetylcholine receptor 2-Go complex 分子名称: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment, ... 著者 Maeda, S, Qianhui, Q, Skiniotis, G, Kobilka, B. 登録日 2019-04-09 公開日 2019-05-08 最終更新日 2020-01-08 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science, 364, 2019
6OMM	Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhuang, Y, Liu, H, de Waal, P.W, Zhou, X.E, Wang, L, Meng, X, Zhao, G, Kang, Y, Melcher, K, Xu, H.E, Zhang, C. 登録日 2019-04-19 公開日 2020-02-26 実験手法 ELECTRON MICROSCOPY (3.17 Å) 主引用文献 Structure of formylpeptide receptor 2-Gicomplex reveals insights into ligand recognition and signaling. Nat Commun, 11, 2020
6ORV	Non-peptide agonist (TT-OAD2) bound to the Glucagon-Like peptide-1 (GLP-1) Receptor 分子名称: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Belousoff, M.J, Liang, Y.L, Danev, R. 登録日 2019-05-01 公開日 2020-01-08 最終更新日 2020-01-29 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Activation of the GLP-1 receptor by a non-peptidic agonist. Nature, 577, 2020
6OT0	Structure of human Smoothened-Gi complex 分子名称: 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-OL, Fab heavy chain, Fab light chain, ... 著者 Qi, X, Li, X. 登録日 2019-05-02 公開日 2019-06-12 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi. Nature, 571, 2019

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