3C15

Complex of GS-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Pyrophosphate and Mg

Summary for 3C15

Entry DOI	10.2210/pdb3c15/pdb
Related	3C14 3C16
Descriptor	Adenylate cyclase type 5, Adenylate cyclase type 2, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (9 entities in total)
Functional Keywords	adenylyl cyclase, gsalpha, pyrophosphate, magnesium, alternative splicing, camp biosynthesis, glycoprotein, lyase, membrane, metal-binding, phosphoprotein, transmembrane, gtp-binding, lipoprotein, nucleotide-binding, palmitate, transducer, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Canis lupus familiaris (Dog) More
Cellular location	Membrane; Multi-pass membrane protein: P30803 P26769 Cell membrane; Lipid-anchor (By similarity): P04896
Total number of polymer chains	3
Total formula weight	97141.51
Authors	Mou, T.-C.,Sprang, S.R. (deposition date: 2008-01-22, release date: 2009-02-03, Last modification date: 2023-08-30)
Primary citation	Mou, T.C.,Masada, N.,Cooper, D.M.,Sprang, S.R. Structural basis for inhibition of mammalian adenylyl cyclase by calcium. Biochemistry, 48:3387-3397, 2009 Cited by PubMed: 19243146 DOI: 10.1021/bi802122k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.78 Å)

Structure validation