6PB1

Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 2 receptor in complex with Gs protein and Nb35

Summary for 6PB1

• Entry DOI: 10.2210/pdb6pb1/pdb
• Related: 6PB0
• EMDB information: 20285
• Descriptor: Corticotropin-releasing factor receptor 2, Urocortin, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (8 entities in total)
• Functional Keywords: corticotropin-releasing factor 2 receptor, urocortins1, gs protein, gpcr, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 157665.83

Authors

Ma, S.,Shen, Q.,Zhao, L.-H.,Mao, C.,Zhou, X.E.,Shen, D.-D.,de Waal, P.W.,Bi, P.,Li, C.,Jiang, Y.,Wang, M.-W.,Sexton, P.M.,Wootten, D.,Melcher, K.,Zhang, Y.,Xu, H.E. (deposition date: 2019-06-12, release date: 2020-02-12, Last modification date: 2020-02-19)

• Primary citation: Ma, S.,Shen, Q.,Zhao, L.H.,Mao, C.,Zhou, X.E.,Shen, D.D.,de Waal, P.W.,Bi, P.,Li, C.,Jiang, Y.,Wang, M.W.,Sexton, P.M.,Wootten, D.,Melcher, K.,Zhang, Y.,Xu, H.E.; Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors.; Mol.Cell, 77:669-, 2020; PubMed: 32004470; DOI: 10.1016/j.molcel.2020.01.013

Experimental method

ELECTRON MICROSCOPY (2.8 Å)