4GNK

Crystal structure of Galphaq in complex with full-length human PLCbeta3

Summary for 4GNK

Entry DOI	10.2210/pdb4gnk/pdb
Descriptor	Guanine nucleotide-binding protein G(q) subunit alpha, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, GUANOSINE-5'-DIPHOSPHATE, ... (8 entities in total)
Functional Keywords	gtp-binding protein alpha subunits, phospholipase c beta, coiled-coil domain, ph domain, ef hand, c2 domain, tim barrel domain, phospholipase, gtp hydrolysis, g-protein signaling, membrane targeting, lipase, hydrolase, calcium binding, gtp binding, phospholipids, gtp-binding protein-hydrolase complex, gtp-binding protein/hydrolase
Biological source	Mus musculus (mouse) More
Cellular location	Nucleus: P21279 Membrane; Peripheral membrane protein: Q01970 Q01970
Total number of polymer chains	5
Total formula weight	393280.92
Authors	Lyon, A.M.,Tesmer, J.J.G. (deposition date: 2012-08-17, release date: 2013-02-06, Last modification date: 2023-09-13)
Primary citation	Lyon, A.M.,Dutta, S.,Boguth, C.A.,Skiniotis, G.,Tesmer, J.J. Full-length G alpha (q)-phospholipase C-beta 3 structure reveals interfaces of the C-terminal coiled-coil domain. Nat.Struct.Mol.Biol., 20:355-362, 2013 Cited by PubMed: 23377541 DOI: 10.1038/nsmb.2497 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4 Å)

Structure validation