4GNK
Crystal structure of Galphaq in complex with full-length human PLCbeta3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 353 | 41538.2 | 2 | UniProt (P21279) Pfam (PF00503) | Mus musculus (mouse) | Guanine nucleotide-binding protein alpha-q |
| 2 | B, D (B, D) | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | polymer | 1235 | 139317.9 | 2 | UniProt (Q01970) Pfam (PF17787) Pfam (PF22631) Pfam (PF00388) Pfam (PF00387) Pfam (PF00168) Pfam (PF08703) | Homo sapiens (human) | Phosphoinositide phospholipase C-beta-3, Phospholipase C-beta-3, PLC-beta-3 |
| 3 | E (E) | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | polymer | 259 | 30347.6 | 1 | UniProt (Q01970) Pfam (PF08703) | Homo sapiens (human) | |
| 4 | F, J (A, C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) PubChem (136073927) | |||
| 5 | G, K (A, C) | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 2 | Chemie (ALF) PubChem (5311325) | |||
| 6 | H, L (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 7 | I, M (B, D) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) PubChem (271) | |||
| 8 | N, O (A, C) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
B, D: 10 - 1234 (UniProt: Q01970)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | expression tag |
| Ala 1 | - | expression tag |
| His 2 | - | expression tag |
| His 3 | - | expression tag |
| His 4 | - | expression tag |
| His 5 | - | expression tag |
| His 6 | - | expression tag |
| His 7 | - | expression tag |
| Gly 8 | - | expression tag |
| Thr 9 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 392059.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1221.1 | |
| All* | Total formula weight | 393280.9 |
