4GNK

Crystal structure of Galphaq in complex with full-length human PLCbeta3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Guanine nucleotide-binding protein G(q) subunit alpha	polymer	353	41538.2	2	UniProt (P21279) Pfam (PF00503)	Mus musculus (mouse)	Guanine nucleotide-binding protein alpha-q
2	B, D (B, D)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	polymer	1235	139317.9	2	UniProt (Q01970) Pfam (PF17787) Pfam (PF22631) Pfam (PF00388) Pfam (PF00387) Pfam (PF00168) Pfam (PF08703)	Homo sapiens (human)	Phosphoinositide phospholipase C-beta-3, Phospholipase C-beta-3, PLC-beta-3
3	E (E)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	polymer	259	30347.6	1	UniProt (Q01970) Pfam (PF08703)	Homo sapiens (human)
4	F, J (A, C)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
5	G, K (A, C)	TETRAFLUOROALUMINATE ION	non-polymer		103.0	2	Chemie (ALF)
6	H, L (A, C)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
7	I, M (B, D)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
8	N, O (A, C)	water	water		18.0	6	Chemie (HOH)

Sequence modifications

B, D: 10 - 1234 (UniProt: Q01970)

PDB	External Database	Details
Met 0	-	expression tag
Ala 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
Gly 8	-	expression tag
Thr 9	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	392059.8
Non-Polymers*	Number of molecules	8
	Total formula weight	1221.1
All*	Total formula weight	393280.9

*Water molecules are not included.