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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4GNK

Crystal structure of Galphaq in complex with full-length human PLCbeta3

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001501biological_processskeletal system development
A0001508biological_processaction potential
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005096molecular_functionGTPase activator activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007206biological_processphospholipase C-activating G protein-coupled glutamate receptor signaling pathway
A0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
A0007208biological_processphospholipase C-activating serotonin receptor signaling pathway
A0007209biological_processphospholipase C-activating tachykinin receptor signaling pathway
A0007215biological_processglutamate receptor signaling pathway
A0007218biological_processneuropeptide signaling pathway
A0007507biological_processheart development
A0008217biological_processregulation of blood pressure
A0009755biological_processhormone-mediated signaling pathway
A0009791biological_processpost-embryonic development
A0009898cellular_componentcytoplasmic side of plasma membrane
A0010543biological_processregulation of platelet activation
A0016020cellular_componentmembrane
A0016322biological_processneuron remodeling
A0016787molecular_functionhydrolase activity
A0019001molecular_functionguanyl nucleotide binding
A0021884biological_processforebrain neuron development
A0030234molecular_functionenzyme regulator activity
A0030425cellular_componentdendrite
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031965cellular_componentnuclear membrane
A0032024biological_processpositive regulation of insulin secretion
A0032278biological_processpositive regulation of gonadotropin secretion
A0034695biological_processresponse to prostaglandin E
A0042711biological_processmaternal behavior
A0042733biological_processembryonic digit morphogenesis
A0043066biological_processnegative regulation of apoptotic process
A0043267biological_processnegative regulation of potassium ion transport
A0043303biological_processmast cell degranulation
A0044297cellular_componentcell body
A0044877molecular_functionprotein-containing complex binding
A0045634biological_processregulation of melanocyte differentiation
A0046872molecular_functionmetal ion binding
A0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
A0048066biological_processdevelopmental pigmentation
A0050821biological_processprotein stabilization
A0060158biological_processphospholipase C-activating dopamine receptor signaling pathway
A0060828biological_processregulation of canonical Wnt signaling pathway
A0071468biological_processcellular response to acidic pH
A0086100biological_processendothelin receptor signaling pathway
A0098793cellular_componentpresynapse
A0099524cellular_componentpostsynaptic cytosol
A0140582biological_processadenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway
A0160025biological_processsensory perception of itch
A1904888biological_processcranial skeletal system development
A1990806biological_processligand-gated ion channel signaling pathway
B0003073biological_processregulation of systemic arterial blood pressure
B0004435molecular_functionphosphatidylinositol-4,5-bisphosphate phospholipase C activity
B0004629molecular_functionC-type glycerophospholipase activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007208biological_processphospholipase C-activating serotonin receptor signaling pathway
B0008081molecular_functionphosphoric diester hydrolase activity
B0016020cellular_componentmembrane
B0016042biological_processlipid catabolic process
B0016787molecular_functionhydrolase activity
B0032991cellular_componentprotein-containing complex
B0035556biological_processintracellular signal transduction
B0045296molecular_functioncadherin binding
B0046488biological_processphosphatidylinositol metabolic process
B0048015biological_processphosphatidylinositol-mediated signaling
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0060090molecular_functionmolecular adaptor activity
B0099524cellular_componentpostsynaptic cytosol
B0120548molecular_functionphosphatidylinositol phospholipase C activity
B0140677molecular_functionmolecular function activator activity
C0000166molecular_functionnucleotide binding
C0001501biological_processskeletal system development
C0001508biological_processaction potential
C0001664molecular_functionG protein-coupled receptor binding
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005096molecular_functionGTPase activator activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005794cellular_componentGolgi apparatus
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0005901cellular_componentcaveola
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007206biological_processphospholipase C-activating G protein-coupled glutamate receptor signaling pathway
C0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
C0007208biological_processphospholipase C-activating serotonin receptor signaling pathway
C0007209biological_processphospholipase C-activating tachykinin receptor signaling pathway
C0007215biological_processglutamate receptor signaling pathway
C0007218biological_processneuropeptide signaling pathway
C0007507biological_processheart development
C0008217biological_processregulation of blood pressure
C0009755biological_processhormone-mediated signaling pathway
C0009791biological_processpost-embryonic development
C0009898cellular_componentcytoplasmic side of plasma membrane
C0010543biological_processregulation of platelet activation
C0016020cellular_componentmembrane
C0016322biological_processneuron remodeling
C0016787molecular_functionhydrolase activity
C0019001molecular_functionguanyl nucleotide binding
C0021884biological_processforebrain neuron development
C0030234molecular_functionenzyme regulator activity
C0030425cellular_componentdendrite
C0031683molecular_functionG-protein beta/gamma-subunit complex binding
C0031965cellular_componentnuclear membrane
C0032024biological_processpositive regulation of insulin secretion
C0032278biological_processpositive regulation of gonadotropin secretion
C0034695biological_processresponse to prostaglandin E
C0042711biological_processmaternal behavior
C0042733biological_processembryonic digit morphogenesis
C0043066biological_processnegative regulation of apoptotic process
C0043267biological_processnegative regulation of potassium ion transport
C0043303biological_processmast cell degranulation
C0044297cellular_componentcell body
C0044877molecular_functionprotein-containing complex binding
C0045634biological_processregulation of melanocyte differentiation
C0046872molecular_functionmetal ion binding
C0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
C0048066biological_processdevelopmental pigmentation
C0050821biological_processprotein stabilization
C0060158biological_processphospholipase C-activating dopamine receptor signaling pathway
C0060828biological_processregulation of canonical Wnt signaling pathway
C0071468biological_processcellular response to acidic pH
C0086100biological_processendothelin receptor signaling pathway
C0098793cellular_componentpresynapse
C0099524cellular_componentpostsynaptic cytosol
C0140582biological_processadenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway
C0160025biological_processsensory perception of itch
C1904888biological_processcranial skeletal system development
C1990806biological_processligand-gated ion channel signaling pathway
D0003073biological_processregulation of systemic arterial blood pressure
D0004435molecular_functionphosphatidylinositol-4,5-bisphosphate phospholipase C activity
D0004629molecular_functionC-type glycerophospholipase activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006629biological_processlipid metabolic process
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
D0007208biological_processphospholipase C-activating serotonin receptor signaling pathway
D0008081molecular_functionphosphoric diester hydrolase activity
D0016020cellular_componentmembrane
D0016042biological_processlipid catabolic process
D0016787molecular_functionhydrolase activity
D0032991cellular_componentprotein-containing complex
D0035556biological_processintracellular signal transduction
D0045296molecular_functioncadherin binding
D0046488biological_processphosphatidylinositol metabolic process
D0048015biological_processphosphatidylinositol-mediated signaling
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0060090molecular_functionmolecular adaptor activity
D0099524cellular_componentpostsynaptic cytosol
D0120548molecular_functionphosphatidylinositol phospholipase C activity
D0140677molecular_functionmolecular function activator activity
E0004435molecular_functionphosphatidylinositol-4,5-bisphosphate phospholipase C activity
E0005509molecular_functioncalcium ion binding
E0016042biological_processlipid catabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues22
DetailsBINDING SITE FOR RESIDUE GDP A 401
ChainResidue
AGLU49
AVAL182
AARG183
AASN274
ALYS275
AASP277
ALEU278
ACYS330
AALA331
ATHR332
AALF402
ASER50
AMG403
AHOH502
AHOH503
AGLY51
ALYS52
ASER53
ATHR54
ASER156
ALEU180
AARG181
site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ALF A 402
ChainResidue
AGLY48
AGLU49
ALYS52
AARG183
APRO185
ATHR186
AGLY208
AGLN209
AGDP401
AMG403
AHOH501
AHOH502
AHOH503
site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 403
ChainResidue
ASER53
ATHR186
AGDP401
AALF402
AHOH502
AHOH503
site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA B 1301
ChainResidue
BASN333
BGLU362
BASP364
BGLU413
site_idAC5
Number of Residues22
DetailsBINDING SITE FOR RESIDUE GDP C 401
ChainResidue
CGLU49
CSER50
CGLY51
CLYS52
CSER53
CTHR54
CSER156
CLEU180
CARG181
CVAL182
CARG183
CASN274
CLYS275
CASP277
CLEU278
CCYS330
CALA331
CTHR332
CALF402
CMG403
CHOH502
CHOH503
site_idAC6
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ALF C 402
ChainResidue
CGLY48
CGLU49
CLYS52
CARG183
CPRO185
CTHR186
CGLY207
CGLY208
CGLN209
CGDP401
CMG403
CHOH501
CHOH502
CHOH503
site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG C 403
ChainResidue
CSER53
CTHR186
CGDP401
CALF402
CHOH502
CHOH503
site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA D 1301
ChainResidue
DASN333
DGLU362
DASP364
DGLU413
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues26
DetailsRegion: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues16
DetailsRegion: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues18
DetailsRegion: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues14
DetailsRegion: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues10
DetailsRegion: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20966218","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7SQ2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20966218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7SQ2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"5-glutamyl histamine","evidences":[{"source":"PubMed","id":"23022564","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues300
DetailsDomain: {"description":"PI-PLC X-box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00270","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues232
DetailsDomain: {"description":"PI-PLC Y-box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00271","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues256
DetailsDomain: {"description":"C2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues22
DetailsCompositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsActive site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00270","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

249524

PDB entries from 2026-02-18

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