8TZQ

CryoEM structure of D2 dopamine receptor in complex with GoA KE Mutant, scFv16, and dopamine

Summary for 8TZQ

Entry DOI	10.2210/pdb8tzq/pdb
EMDB information	41766
Descriptor	scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	gpcr, dopamine, drd2, dominant negative, membrane protein
Biological source	Escherichia coli More
Total number of polymer chains	5
Total formula weight	166887.12
Authors	Krumm, B.E.,Kapolka, N.J.,Fay, J.F.,Roth, B.L. (deposition date: 2023-08-27, release date: 2024-08-21)
Primary citation	Knight, K.M.,Krumm, B.E.,Kapolka, N.J.,Ludlam, W.G.,Cui, M.,Mani, S.,Prytkova, I.,Obarow, E.G.,Lefevre, T.J.,Wei, W.,Ma, N.,Huang, X.P.,Fay, J.F.,Vaidehi, N.,Smrcka, A.V.,Slesinger, P.A.,Logothetis, D.E.,Martemyanov, K.A.,Roth, B.L.,Dohlman, H.G. A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state. Nat Commun, 15:6643-6643, 2024 Cited by PubMed: 39103320 DOI: 10.1038/s41467-024-50964-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation