8TZQ
CryoEM structure of D2 dopamine receptor in complex with GoA KE Mutant, scFv16, and dopamine
Functional Information from PROSITE/UniProt
site_id | PS00237 |
Number of Residues | 17 |
Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIlNLCAISIDRYTaV |
Chain | Residue | Details |
R | ALA120-VAL136 |
site_id | PS00678 |
Number of Residues | 15 |
Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
Chain | Residue | Details |
A | LEU70-SER84 | |
A | ILE157-ILE171 | |
A | LEU285-ALA299 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 7 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
B | GLY40 | |
B | SER47 | |
B | LEU176 | |
B | THR182 | |
B | ASP201 | |
B | ASN270 | |
B | ALA326 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250 |
Chain | Residue | Details |
B | ARG179 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: 5-glutamyl histamine => ECO:0000250|UniProtKB:P18872 |
Chain | Residue | Details |
B | GLN205 | |
R | ASP131-ARG151 | |
R | ILE214-GLN373 | |
R | GLU432-CYS443 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: ADP-ribosylcysteine; by pertussis toxin => ECO:0000250 |
Chain | Residue | Details |
B | CYS351 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | LIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805 |
Chain | Residue | Details |
B | GLY2 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
Chain | Residue | Details |
B | CYS3 |
site_id | SWS_FT_FI7 |
Number of Residues | 24 |
Details | TRANSMEM: Helical; Name=5 => ECO:0000250 |
Chain | Residue | Details |
R | PHE189-TYR213 |
site_id | SWS_FT_FI8 |
Number of Residues | 21 |
Details | TRANSMEM: Helical; Name=6 => ECO:0000250 |
Chain | Residue | Details |
R | MET374-LEU395 |
site_id | SWS_FT_FI9 |
Number of Residues | 21 |
Details | TRANSMEM: Helical; Name=7 => ECO:0000250 |
Chain | Residue | Details |
R | ALA410-ILE431 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | SITE: Important for receptor activation => ECO:0000250 |
Chain | Residue | Details |
R | SER194 | |
R | SER197 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:26535572 |
Chain | Residue | Details |
R | CYS443 |
site_id | SWS_FT_FI12 |
Number of Residues | 3 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
R | ASN5 | |
R | ASN17 | |
R | ASN23 |