8TZQ
CryoEM structure of D2 dopamine receptor in complex with GoA KE Mutant, scFv16, and dopamine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | E | scFv16 | polymer | 267 | 28668.9 | 1 | Escherichia coli | ||
2 | A | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39418.1 | 1 | UniProt (P62873) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) In PDB | Homo sapiens (human) | G gamma-I |
4 | R | D(2) dopamine receptor | polymer | 443 | 50685.4 | 1 | UniProt (P14416) In PDB | Homo sapiens (human) | |
5 | B | Guanine nucleotide-binding protein G(o) subunit alpha | polymer | 354 | 40100.4 | 1 | UniProt (P09471) In PDB | Homo sapiens (human) | |
6 | R | L-DOPAMINE | non-polymer | 153.2 | 1 | Chemie (LDP) |
Sequence modifications
A: 2 - 340 (UniProt: P62873)
B: 1 - 354 (UniProt: P09471)
PDB | External Database | Details |
---|---|---|
Met -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Glu 46 | Lys 46 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 166733.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 153.2 | |
All* | Total formula weight | 166887.1 |