1N4P
| Protein Geranylgeranyltransferase type-I Complexed with Geranylgeranyl Diphosphate | 分子名称: | CHLORIDE ION, Fusion protein consisting of transforming protein p21b and Ras related protein Rap-2b, GERAN-8-YL GERAN, ... | 著者 | Taylor, J.S, Reid, T.S, Casey, P.J, Beese, L.S. | 登録日 | 2002-11-01 | 公開日 | 2003-11-18 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structure of mammalian protein geranylgeranyltransferase type-I EMBO J., 22, 2003
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1N4Q
| Protein Geranylgeranyltransferase type-I Complexed with a GGPP Analog and a KKKSKTKCVIL Peptide | 分子名称: | 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE, CHLORIDE ION, Fusion protein consisting of transforming protein p21b and Ras related protein Rap-2b, ... | 著者 | Taylor, J.S, Reid, T.S, Casey, P.J, Beese, L.S. | 登録日 | 2002-11-01 | 公開日 | 2003-11-18 | 最終更新日 | 2017-06-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of mammalian protein geranylgeranyltransferase type-I EMBO J., 22, 2003
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1N4S
| Protein Geranylgeranyltransferase type-I Complexed with GGPP and a Geranylgeranylated KKKSKTKCVIL Peptide Product | 分子名称: | CHLORIDE ION, Fusion protein consisting of transforming protein p21b and Ras related protein Rap-2b, GERAN-8-YL GERAN, ... | 著者 | Taylor, J.S, Reid, T.S, Casey, P.J, Beese, L.S. | 登録日 | 2002-11-01 | 公開日 | 2003-11-18 | 最終更新日 | 2017-06-28 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of mammalian protein geranylgeranyltransferase type-I EMBO J., 22, 2003
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1O1R
| Structure of FPT bound to GGPP | 分子名称: | GERANYLGERANYL DIPHOSPHATE, Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ... | 著者 | Turek-Etienne, T.C, Strickland, C.L, Distefano, M.D. | 登録日 | 2003-01-14 | 公開日 | 2003-05-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Biochemical and Structural Studies with Prenyl Diphosphate Analogues Provide Insights
into Isoprenoid Recognition by Protein Farnesyl Transferase Biochemistry, 42, 2003
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1D8E
| Zinc-depleted FTase complexed with K-RAS4B peptide substrate and FPP analog. | 分子名称: | ACETATE ION, FARNESYLTRANSFERASE (ALPHA SUBUNIT), FARNESYLTRANSFERASE (BETA SUBUNIT), ... | 著者 | Long, S.B, Casey, P.J, Beese, L.S. | 登録日 | 1999-10-22 | 公開日 | 2000-03-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures. Structure Fold.Des., 8, 2000
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1KZP
| PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A FARNESYLATED K-RAS4B PEPTIDE PRODUCT | 分子名称: | ACETIC ACID, FARNESYL, Farnesylated K-Ras4B peptide product, ... | 著者 | Long, S.B, Casey, P.J, Beese, L.S. | 登録日 | 2002-02-07 | 公開日 | 2002-10-16 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Reaction path of protein farnesyltransferase at atomic resolution Nature, 419, 2002
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1O1S
| Structure of FPT bound to isoprenoid analog 3b | 分子名称: | (2E,6E)-8-[(3-BENZOYLBENZYL)OXY]-3,7-DIMETHYLOCTA-2,6-DIENYL TRIHYDROGEN DIPHOSPHATE, Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ... | 著者 | Turek-Etienne, T.C, Strickland, C.L, Distefano, M.D. | 登録日 | 2003-01-14 | 公開日 | 2003-05-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Biochemical and Structural Studies with Prenyl Diphosphate Analogues Provide Insights into
Isoprenoid Recognition by Protein Farnesyl Transferase Biochemistry, 42, 2003
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1KZO
| PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYLATED K-RAS4B PEPTIDE PRODUCT AND FARNESYL DIPHOSPHATE SUBSTRATE BOUND SIMULTANEOUSLY | 分子名称: | ACETIC ACID, FARNESYL, FARNESYL DIPHOSPHATE, ... | 著者 | Long, S.B, Casey, P.J, Beese, L.S. | 登録日 | 2002-02-07 | 公開日 | 2002-10-16 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Reaction Path of Protein Farnesyltransferase at Atomic Resolution Nature, 419, 2002
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1O5M
| Structure of FPT bound to the inhibitor SCH66336 | 分子名称: | 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE, FARNESYL DIPHOSPHATE, Protein farnesyltransferase alpha subunit, ... | 著者 | Strickland, C.L, Weber, P.C, Ganguly, A.K. | 登録日 | 2003-09-26 | 公開日 | 2003-10-21 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure-Activity Relationships J.Med.Chem., 42, 1999
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1O1T
| Structure of FPT bound to the CVIM-FPP product | 分子名称: | MAGNESIUM ION, N-ACETYL-S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]-L-CYSTEINYL-D-VALYL-L-ISOLEUCYL-L-METHIONINE, Protein farnesyltransferase alpha subunit, ... | 著者 | Turek-Etienne, T.C, Strickland, C.L, Distefano, M.D. | 登録日 | 2003-01-14 | 公開日 | 2003-05-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Biochemical and Structural Studies with Prenyl Diphosphate Analogues Provide Insights into
Isoprenoid Recognition by Protein Farnesyl Transferase Biochemistry, 42, 2003
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1FT1
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1FPP
| PROTEIN FARNESYLTRANSFERASE COMPLEX WITH FARNESYL DIPHOSPHATE | 分子名称: | FARNESYL DIPHOSPHATE, PHOSPHATE ION, PROTEIN FARNESYLTRANSFERASE, ... | 著者 | Dunten, P, Kammlott, U, Crowther, R, Weber, D, Palermo, R, Birktoft, J. | 登録日 | 1998-07-10 | 公開日 | 1999-06-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Protein farnesyltransferase: structure and implications for substrate binding. Biochemistry, 37, 1998
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1SA5
| Rat protein farnesyltransferase complexed with FPP and BMS-214662 | 分子名称: | 3-BENZYL-1-(1H-IMIDAZOL-4-YLMETHYL)-4-(THIEN-2-YLSULFONYL)-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE, ACETIC ACID, FARNESYL DIPHOSPHATE, ... | 著者 | Reid, T.S, Beese, L.S. | 登録日 | 2004-02-06 | 公開日 | 2004-06-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structures of the Anticancer Clinical Candidates R115777 (Tipifarnib) and BMS-214662 Complexed with Protein Farnesyltransferase Suggest a Mechanism of FTI Selectivity. Biochemistry, 43, 2004
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1TN7
| Protein Farnesyltransferase Complexed with a TC21 Peptide Substrate and a FPP Analog at 2.3A Resolution | 分子名称: | ACETIC ACID, Fusion protein, Protein farnesyltransferase alpha subunit, ... | 著者 | Reid, T.S, Terry, K.L, Casey, P.J, Beese, L.S. | 登録日 | 2004-06-11 | 公開日 | 2004-11-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J.Mol.Biol., 343, 2004
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1TNU
| Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a GCINCCKVL Peptide Derived from RhoB | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE, CHLORIDE ION, ... | 著者 | Reid, T.S, Terry, K.L, Casey, P.J, Beese, L.S. | 登録日 | 2004-06-11 | 公開日 | 2004-11-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J.Mol.Biol., 343, 2004
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1TNB
| Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a substrate KKSKTKCVIF Peptide Derived from TC21 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE, CHLORIDE ION, ... | 著者 | Reid, T.S, Terry, K.L, Casey, P.J, Beese, L.S. | 登録日 | 2004-06-11 | 公開日 | 2004-11-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J.Mol.Biol., 343, 2004
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1TNO
| Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a KKKSKTKCVIM Peptide Derived from K-Ras4B | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE, CHLORIDE ION, ... | 著者 | Reid, T.S, Terry, K.L, Casey, P.J, Beese, L.S. | 登録日 | 2004-06-11 | 公開日 | 2004-11-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J.Mol.Biol., 343, 2004
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1S64
| Rat protein geranylgeranyltransferase type-I complexed with L-778,123 and a sulfate anion | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE, CHLORIDE ION, ... | 著者 | Reid, T.S, Long, S.B, Beese, L.S. | 登録日 | 2004-01-22 | 公開日 | 2004-07-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Crystallographic Analysis Reveals that Anticancer Clinical Candidate L-778,123 Inhibits Protein Farnesyltransferase and Geranylgeranyltransferase-I by Different Binding Modes. Biochemistry, 43, 2004
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1TN8
| Protein Farnesyltransferase Complexed with a H-Ras Peptide Substrate and a FPP Analog at 2.25A Resolution | 分子名称: | ACETIC ACID, Protein farnesyltransferase beta subunit, Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, ... | 著者 | Reid, T.S, Terry, K.L, Casey, P.J, Beese, L.S. | 登録日 | 2004-06-11 | 公開日 | 2004-11-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J.Mol.Biol., 343, 2004
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1TNY
| Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a FREKKFFCAIL Peptide Derived from the Heterotrimeric G Protein Gamma-2 Subunit | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE, CHLORIDE ION, ... | 著者 | S Reid, T, Terry, K.L, Casey, P.J, Beese, L.S. | 登録日 | 2004-06-11 | 公開日 | 2004-11-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J.Mol.Biol., 343, 2004
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1TNZ
| Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a RRCVLL Peptide Derived from Cdc42 splice isoform-2 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE, CHLORIDE ION, ... | 著者 | Reid, T.S, Terry, K.L, Casey, P.J, Beese, L.S. | 登録日 | 2004-06-11 | 公開日 | 2004-11-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J.Mol.Biol., 343, 2004
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1JCS
| CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE PEPTIDE SUBSTRATE TKCVFM AND AN ANALOG OF FARNESYL DIPHOSPHATE | 分子名称: | ACETIC ACID, PROTEIN FARNESYLTRANSFERASE, ALPHA SUBUNIT, ... | 著者 | Long, S.B, Casey, P.J, Beese, L.S. | 登録日 | 2001-06-11 | 公開日 | 2001-11-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. Proc.Natl.Acad.Sci.USA, 98, 2001
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1JCR
| CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE NON-SUBSTRATE TETRAPEPTIDE INHIBITOR CVFM AND FARNESYL DIPHOSPHATE SUBSTRATE | 分子名称: | ACETIC ACID, FARNESYL DIPHOSPHATE, PROTEIN FARNESYLTRANSFERASE, ... | 著者 | Long, S.B, Casey, P.J, Beese, L.S. | 登録日 | 2001-06-11 | 公開日 | 2001-11-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. Proc.Natl.Acad.Sci.USA, 98, 2001
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8E9E
| Rat protein farnesyltransferase in complex with FPP and inhibitor 2f | 分子名称: | (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | Wang, Y, Shi, Y, Beese, L.S. | 登録日 | 2022-08-26 | 公開日 | 2022-10-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.844 Å) | 主引用文献 | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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2MGY
| Solution structure of the mitochondrial translocator protein (TSPO) in complex with its high-affinity ligand PK11195 | 分子名称: | N-[(2R)-butan-2-yl]-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide, Translocator protein | 著者 | Jaremko, M, Jaremko, L, Giller, K, Becker, S, Zweckstetter, M. | 登録日 | 2013-11-11 | 公開日 | 2014-04-02 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science, 343, 2014
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