1SA5

Rat protein farnesyltransferase complexed with FPP and BMS-214662

Summary for 1SA5

• Entry DOI: 10.2210/pdb1sa5/pdb
• Related: 1D8D 1FT1 1JCQ 1JCR 1LD8 1O5M 1SA4
• Descriptor: Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (7 entities in total)
• Functional Keywords: ftase, farnesyltransferase, farnesyl transferase, caax, ras, cancer, tumor regression, bms-214662, fti, clinical candidate, inhibitor, protein prenylation, lipid modification, transferase
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 2
• Total formula weight: 93817.82

Authors

Reid, T.S.,Beese, L.S. (deposition date: 2004-02-06, release date: 2004-06-08, Last modification date: 2023-08-23)

• Primary citation: Reid, T.S.,Beese, L.S.; Crystal Structures of the Anticancer Clinical Candidates R115777 (Tipifarnib) and BMS-214662 Complexed with Protein Farnesyltransferase Suggest a Mechanism of FTI Selectivity.; Biochemistry, 43:6877-6884, 2004; PubMed: 15170324; DOI: 10.1021/bi049723b

Experimental method

X-RAY DIFFRACTION (2.6 Å)