1JCQ

CRYSTAL STRUCTURE OF HUMAN PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYL DIPHOSPHATE AND THE PEPTIDOMIMETIC INHIBITOR L-739,750

Summary for 1JCQ

Entry DOI	10.2210/pdb1jcq/pdb
Related	1D8D 1FT1 1JCR 1JCS
Related PRD ID	PRD_900003
Descriptor	PROTEIN FARNESYLTRANSFERASE, ALPHA SUBUNIT, PROTEIN FARNESYLTRANSFERASE, BETA SUBUNIT, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (8 entities in total)
Functional Keywords	ftase, pft, pftase, ft, fpt, farnesyltransferase, farnesyl transferase, farnesyl protein transferase, caax, ras, cancer, tumor regression, l-739, 750, peptidomimetic, inhibitor, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	95055.03
Authors	Long, S.B.,Casey, P.J.,Beese, L.S. (deposition date: 2001-06-11, release date: 2001-11-02, Last modification date: 2023-08-16)
Primary citation	Long, S.B.,Hancock, P.J.,Kral, A.M.,Hellinga, H.W.,Beese, L.S. The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. Proc.Natl.Acad.Sci.USA, 98:12948-12953, 2001 Cited by PubMed: 11687658 DOI: 10.1073/pnas.241407898 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation