1JCS

CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE PEPTIDE SUBSTRATE TKCVFM AND AN ANALOG OF FARNESYL DIPHOSPHATE

Summary for 1JCS
Related1D8D 1FT1 1JCQ 1JCR
DescriptorPROTEIN FARNESYLTRANSFERASE, ALPHA SUBUNIT, PROTEIN FARNESYLTRANSFERASE, BETA SUBUNIT, SYNTHETIC HEXAPEPTIDE TKCVFM, ... (7 entities in total)
Functional Keywordsftase, pft, pftase, ft, fpt, farnesyltransferase, farnesyl transferase, farnesyl protein transferase, caax, ras, cancer, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceRattus norvegicus (Norway rat)
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Total number of polymer chains3
Total formula weight94094.28
Authors
Long, S.B.,Casey, P.J.,Beese, L.S. (deposition date: 2001-06-11, release date: 2001-11-02, Last modification date: 2011-07-13)
Primary citationBeese, L.S.,Hancock, P.J.,Hellinga, H.W.,Kral, A.M.,Long, S.B.
The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
Proc.Natl.Acad.Sci.USA, 98:12948-12953, 2001
PubMed: 11687658
DOI: 110.1073/pnas.241407898
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation
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PDB entries from 2021-06-09