1JCQ
CRYSTAL STRUCTURE OF HUMAN PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYL DIPHOSPHATE AND THE PEPTIDOMIMETIC INHIBITOR L-739,750
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PROTEIN FARNESYLTRANSFERASE, ALPHA SUBUNIT | polymer | 382 | 44864.8 | 1 | UniProt (P49354) Pfam (PF01239) | Homo sapiens (human) | CAAX FARNESYLTRANSFERASE ALPHA SUBUNIT; RAS PROTEINS PRENYLTRANSFERASE ALPHA; FTASE-ALPHA; PRENYL-PROTEIN TRANSFERASE RAM2 HOMOLOG |
| 2 | B (B) | PROTEIN FARNESYLTRANSFERASE, BETA SUBUNIT | polymer | 437 | 48822.4 | 1 | UniProt (P49356) Pfam (PF00432) | Homo sapiens (human) | CAAX FARNESYLTRANSFERASE BETA SUBUNIT; RAS PROTEINS PRENYLTRANSFERASE BETA; FTASE-BETA; PRENYL-PROTEIN TRANSFERASE DPR1/RAM1 SUBUNIT |
| 3 | C (C) | beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900003) | sucrose | ||
| 4 | D (A) | ACETIC ACID | non-polymer | 60.1 | 1 | Chemie (ACY) | |||
| 5 | E (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | F (B) | FARNESYL DIPHOSPHATE | non-polymer | 382.3 | 1 | Chemie (FPP) | |||
| 7 | G (B) | 2(S)-{2(S)-[2(R)-AMINO-3-MERCAPTO]PROPYLAMINO-3(S)-METHYL}PENTYLOXY-3-PHENYLPROPIONYLMETHIONINE SULFONE | non-polymer | 517.7 | 1 | Chemie (739) | |||
| 8 | H, I (A, B) | water | water | 18.0 | 334 | Chemie (HOH) |
Sequence modifications
A: 1 - 379 (UniProt: P49354)
| PDB | External Database | Details |
|---|---|---|
| Glu 380 | - | insertion |
| Glu 381 | - | insertion |
| Phe 382 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 93687.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 342.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1025.5 | |
| All* | Total formula weight | 95055.0 |
