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1JCR

CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE NON-SUBSTRATE TETRAPEPTIDE INHIBITOR CVFM AND FARNESYL DIPHOSPHATE SUBSTRATE

Summary for 1JCR
Entry DOI10.2210/pdb1jcr/pdb
Related1D8D 1FT1 1JCQ 1JCS
DescriptorPROTEIN FARNESYLTRANSFERASE, ALPHA SUBUNIT, PROTEIN FARNESYLTRANSFERASE, BETA SUBUNIT, SYNTHETIC TETRAPEPTIDE CVFM, ... (7 entities in total)
Functional Keywordsftase, pft, pftase, ft, fpt, farnesyltransferase, farnesyl transferase, farnesyl protein transferase, caax, ras, cancer, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceRattus norvegicus (Norway rat)
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Total number of polymer chains3
Total formula weight93886.92
Authors
Long, S.B.,Casey, P.J.,Beese, L.S. (deposition date: 2001-06-11, release date: 2001-11-02, Last modification date: 2023-08-16)
Primary citationLong, S.B.,Hancock, P.J.,Kral, A.M.,Hellinga, H.W.,Beese, L.S.
The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
Proc.Natl.Acad.Sci.USA, 98:12948-12953, 2001
Cited by
PubMed: 11687658
DOI: 10.1073/pnas.241407898
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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