8E9E

Rat protein farnesyltransferase in complex with FPP and inhibitor 2f

Summary for 8E9E

Entry DOI	10.2210/pdb8e9e/pdb
Related	7T08 7T09 7T0A 7T0B 7T0C 7T0D 7T0E
Descriptor	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Protein farnesyltransferase subunit beta, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (8 entities in total)
Functional Keywords	inhibitor, protein prenylyltransferase, antifungal, transferase, transferase-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	2
Total formula weight	94880.77
Authors	Wang, Y.,Shi, Y.,Beese, L.S. (deposition date: 2022-08-26, release date: 2022-10-26, Last modification date: 2023-10-18)
Primary citation	Wang, Y.,Xu, F.,Nichols, C.B.,Shi, Y.,Hellinga, H.W.,Alspaugh, J.A.,Distefano, M.D.,Beese, L.S. Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65:13753-13770, 2022 Cited by PubMed: 36218371 DOI: 10.1021/acs.jmedchem.2c00902 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.844 Å)

Structure validation